Investigation of the role of GPR56 in human NK cell biology
碩士 === 長庚大學 === 生物醫學研究所 === 100 === Natural killer (NK) cells play an important role in innate immunity. NK cells possess a natural cytotoxic potential against virus-infected cells and tumor cells without priming. NK cells secret cytokines to coordinate innate and adaptive immunity by a variety of g...
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ndltd-TW-100CGU051140692015-10-13T21:28:02Z http://ndltd.ncl.edu.tw/handle/33157544982743383327 Investigation of the role of GPR56 in human NK cell biology 探討GPR56在人類NK細胞所扮演的角色 Mei Hui Huang 黃美惠 碩士 長庚大學 生物醫學研究所 100 Natural killer (NK) cells play an important role in innate immunity. NK cells possess a natural cytotoxic potential against virus-infected cells and tumor cells without priming. NK cells secret cytokines to coordinate innate and adaptive immunity by a variety of germ-line encoded receptors that can be classified into activating, inhibitory, adhesion, cytokine and chemokine receptors. Recently, a specific member of the G protein-coupled receptors, GPR56 has been found to be abundantly expressed in NK cells. However, its function has remained mysterious. GPR56 is involved in cell to cell, cell and matrix interaction in other cell types. GPR56 is able to associate with CD81. We used a stable GPR56 over-expressing NK92 cell line and specific antibody stimuli on fresh peripheral blood NK cells to investigate the biological functions of GPR56 in NK cells. Our data suggests that GPR56 is able to regulate the motility of NK cells, affect cytokine secretion and cytotoxicity when recognizing target cells. Indeed, GPR56 might interact with CD81 to regulate the biological functions of NK cells. H. H. Lin 林錫賢 2012 學位論文 ; thesis 56 |
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碩士 === 長庚大學 === 生物醫學研究所 === 100 === Natural killer (NK) cells play an important role in innate immunity. NK cells possess a natural cytotoxic potential against virus-infected cells and tumor cells without priming. NK cells secret cytokines to coordinate innate and adaptive immunity by a variety of germ-line encoded receptors that can be classified into activating, inhibitory, adhesion, cytokine and chemokine receptors. Recently, a specific member of the G protein-coupled receptors, GPR56 has been found to be abundantly expressed in NK cells. However, its function has remained mysterious. GPR56 is involved in cell to cell, cell and matrix interaction in other cell types. GPR56 is able to associate with CD81. We used a stable GPR56 over-expressing NK92 cell line and specific antibody stimuli on fresh peripheral blood NK cells to investigate the biological functions of GPR56 in NK cells. Our data suggests that GPR56 is able to regulate the motility of NK cells, affect cytokine secretion and cytotoxicity when recognizing target cells. Indeed, GPR56 might interact with CD81 to regulate the biological functions of NK cells.
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H. H. Lin |
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H. H. Lin Mei Hui Huang 黃美惠 |
author |
Mei Hui Huang 黃美惠 |
spellingShingle |
Mei Hui Huang 黃美惠 Investigation of the role of GPR56 in human NK cell biology |
author_sort |
Mei Hui Huang |
title |
Investigation of the role of GPR56 in human NK cell biology |
title_short |
Investigation of the role of GPR56 in human NK cell biology |
title_full |
Investigation of the role of GPR56 in human NK cell biology |
title_fullStr |
Investigation of the role of GPR56 in human NK cell biology |
title_full_unstemmed |
Investigation of the role of GPR56 in human NK cell biology |
title_sort |
investigation of the role of gpr56 in human nk cell biology |
publishDate |
2012 |
url |
http://ndltd.ncl.edu.tw/handle/33157544982743383327 |
work_keys_str_mv |
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1718064516329111552 |