| Summary: | 碩士 === 中國醫藥大學 === 生物科技學系碩士班 === 100 === The skin is comprised of the epidermis, dermis, and subcutis to maintain body temperature and touch. The skin provides protection from bacterial infections. In the event of injury, the skin initiates a cascade of events including tissue fluid secretions, inflammation, and tissue remodeling. An ideal wound dressing should efficiently absorb tissue fluids, prevent bacterial infection, and reduce the severity of inflammation. It was known that epigallocatechin-3-gallate inhibits wound inflammation. In addition, a porous carbon is suited for efficient adsorption of large inflammatory proteins. The activated carbon fibers are biocompatible and ideal for three-dimensional scaffolds to enhance cell growth, proliferation, or tissue engineering. Our objectives were to produce an activated carbon fiber with gentamicin wound dressings that are composed of hydrophilic nanoparticles to encapsulate epigallocatechin-3-gallate to examine the physicochemical characteristics and antimicrobial properties of the material to better determine fibroblast cell viability upon exposure to the dressing material. Additionally, we preformed in vivo experiments using rat models to compare wound healing with the prepared wound dressings versus commercially available products. Additionally, the wound site in our prepared wound dressing reduced inflammation reaction and neo-collagen regeneration better than that achieved using an Alginate Tegaderm™ hydrocolloid dressing. The result was found that the epigallocatechin-3-gallate-loaded nanoparticles in wound dressing have demonstrated potential of biologically functionalized dressings to accelerate wound closure to show enhanced clinical usefulness.
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