Chemical Constituents and Biological Investigations of Fissistigma cupreonitens
碩士 === 中國醫藥大學 === 藥物化學研究所碩士班 === 100 === The genus Fissistigma (Annonaceae) has been used in Chinese folk medicine. Previous studies showed various biological activities such as analgesic, anti-inflammatory, antimicrobial, anti-tumor and cardiovascular effects. In order to develop new medicine r...
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ndltd-TW-100CMCH55490122015-10-13T21:32:33Z http://ndltd.ncl.edu.tw/handle/78539352937665182911 Chemical Constituents and Biological Investigations of Fissistigma cupreonitens 金果瓜馥木化學成分及其生物活性之研究 Ming-Yi Yang 楊名詣 碩士 中國醫藥大學 藥物化學研究所碩士班 100 The genus Fissistigma (Annonaceae) has been used in Chinese folk medicine. Previous studies showed various biological activities such as analgesic, anti-inflammatory, antimicrobial, anti-tumor and cardiovascular effects. In order to develop new medicine resources, active compounds were isolated and purified from Fissistigma cupreonitens, with no report in prior investigation . There were thirty eight compounds isolated through F. cupreonitens crude extracts, and their structures were established by NMR spectroscopy and references comparing. These compounds including seventeen alkaloids, oxoxylopine (1), oxoisocalycinine (2), oxocrebanine (3), kuafumine (4), lysicamine (5), noraistolodione (6), norcepharadione B (7), aristolactam AII (8), aristolactam AIIIa (9), aristolactam FII (10), goniothalactam (11), piperlactam A (12), piperlactam C (13), isostigmalactam (14), aristolactam AIa (15), N-trans-feruloyltyramine (16) and N-cis-feruloyltyramine (17) ; ten flavonoids, pinostrobin (18), 5-hydroxy-7,8-dimethoxyflavanone (19), isovitexin (20), isoorientin (21), orientin (22), 2'',6''-dihydroxy-3'',4''- dimethoxydihydrochalcone (23), 2'',6''-dihydroxy-4''-methoxydihydrochalcone (24), piperaduncin C (25), adunctin E (26) and hostmanin C (27) ; four steroids, β-sitosterol (28), β-sitosterol-D-glucoside (29), stigmasterol (30) and stigmasterol-D-glucoside (31) ; a triterpenoid, taraxerol (32) ; four benzenoids, syringic acid (33), vanillic acid (34), methyl ferulate (35) and methyl-p-coumarate (36) ; one ionone, boscialin (37) and one sesquiterpenoid, abscisic acid (38). Among these compound, (15), (20), (21), (22), (23), (24), (25), (26), (27), (35), (36), (37) and (38) were isolated for the first time in the genus Fissistigma. After all compounds were evaluated for anti-tumor activity, compound (1), (3), (4), (5) and (26) demonstrated cytotoxicity for NPC-TW01 and NCI-H226 cell lines; compound (6), (24) and (11) exhibited cytotoxicity for Jurkat E6-1 cell line. 藍于琁 2012 學位論文 ; thesis 161 zh-TW |
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碩士 === 中國醫藥大學 === 藥物化學研究所碩士班 === 100 === The genus Fissistigma (Annonaceae) has been used in Chinese folk medicine. Previous studies showed various biological activities such as analgesic, anti-inflammatory, antimicrobial, anti-tumor and cardiovascular effects. In order to develop new medicine resources, active compounds were isolated and purified from Fissistigma cupreonitens, with no report in prior investigation .
There were thirty eight compounds isolated through F. cupreonitens crude extracts, and their structures were established by NMR spectroscopy and references comparing. These compounds including seventeen alkaloids, oxoxylopine (1), oxoisocalycinine (2), oxocrebanine (3), kuafumine (4), lysicamine (5), noraistolodione (6), norcepharadione B (7), aristolactam AII (8), aristolactam AIIIa (9), aristolactam FII (10), goniothalactam (11), piperlactam A (12), piperlactam C (13), isostigmalactam (14), aristolactam AIa (15), N-trans-feruloyltyramine (16) and N-cis-feruloyltyramine (17) ; ten flavonoids, pinostrobin (18), 5-hydroxy-7,8-dimethoxyflavanone (19), isovitexin (20), isoorientin (21), orientin (22), 2'',6''-dihydroxy-3'',4''- dimethoxydihydrochalcone (23), 2'',6''-dihydroxy-4''-methoxydihydrochalcone (24), piperaduncin C (25), adunctin E (26) and hostmanin C (27) ; four steroids, β-sitosterol (28), β-sitosterol-D-glucoside (29), stigmasterol (30) and stigmasterol-D-glucoside (31) ; a triterpenoid, taraxerol (32) ; four benzenoids, syringic acid (33), vanillic acid (34), methyl ferulate (35) and methyl-p-coumarate (36) ; one ionone, boscialin (37) and one sesquiterpenoid, abscisic acid (38). Among these compound, (15), (20), (21), (22), (23), (24), (25), (26), (27), (35), (36), (37) and (38) were isolated for the first time in the genus Fissistigma.
After all compounds were evaluated for anti-tumor activity, compound (1), (3), (4), (5) and (26) demonstrated cytotoxicity for NPC-TW01 and NCI-H226 cell lines; compound (6), (24) and (11) exhibited cytotoxicity for Jurkat E6-1 cell line.
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author2 |
藍于琁 |
author_facet |
藍于琁 Ming-Yi Yang 楊名詣 |
author |
Ming-Yi Yang 楊名詣 |
spellingShingle |
Ming-Yi Yang 楊名詣 Chemical Constituents and Biological Investigations of Fissistigma cupreonitens |
author_sort |
Ming-Yi Yang |
title |
Chemical Constituents and Biological Investigations of Fissistigma cupreonitens |
title_short |
Chemical Constituents and Biological Investigations of Fissistigma cupreonitens |
title_full |
Chemical Constituents and Biological Investigations of Fissistigma cupreonitens |
title_fullStr |
Chemical Constituents and Biological Investigations of Fissistigma cupreonitens |
title_full_unstemmed |
Chemical Constituents and Biological Investigations of Fissistigma cupreonitens |
title_sort |
chemical constituents and biological investigations of fissistigma cupreonitens |
publishDate |
2012 |
url |
http://ndltd.ncl.edu.tw/handle/78539352937665182911 |
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