| Summary: | 碩士 === 中臺科技大學 === 健康產業管理研究所 === 100 === Purpose: This study aims to explore the recurrence metastasis and survival after treatment in oral cancer patients of a Medical center in central Taiwan. Analysis of prognosis and survival differences. In addition, for patients with different treatment effectiveness analysis and further improve the quality of oral cancer clinics improved.
Methods: Object of study was obtained from april 2000 to August 2010 of medical center in the central Taiwan. Use of ICD-10 of International Classification of Diseases code, extract have clinical records and pathological biopsy of oral cancer patients, there were 898 patients chosen for the final analyses. Study chart records were retrospectively reviewed, include sociodemographic, personal habits, personal disease, cancer-related symptoms and patient status after treatment. Statistical methods used Descriptive statistics of population distribution and the percentage, Chi-square test analysis of the correlation in patient of recurrence metastasis and survival status, One-way ANOVA analysis of the differences in patient impact of recurrence metastasis and survival status, Kaplan-Meier survival analysis and Log-Rank test depict the survival curve and estimate the five-year survival rate and the relationship between survival of oral cancer patients.
Results: In this study, 898 patients were male (N=842,93.8%) and 56 were female (6.2%); the male-to-female ratio was 15.13: 1. The mean age at diagnosis was 51.95 year old. Most of the 60.1% patients had smoking, drinking and betel nut chewing habits; Buccal mucosa (33.1%) and tongue (27.8%) were the most common locations of involvement. The most common stage was stage IV (41.6%)；The overall recurrence rate was 38.1%, metastasis rate was 11%; Treatment of the survival highest In the whole surgical. Using Kaplan-Meier survival Analysis, the overall 5-year survival rate was 46.8%. According to the Log-Rank Test, we found the most important factors that correlated to survival were：tumor stage, tumor size, degree of differentiation, lymph node dissection, lymph node metastasis number , treatment.
Conclusion: This study retrospectively reviewed 898 oral cancer patients and found that treatment and lymph node dissection have a significant correlation with recurrence, metastasis and survival rate. Although surgery is the gold standard for oral cancer treatment, further investigation with a prospective cohort study is needed to further clarify the relationship between physical and psychological factors and the survival of oral cancer patients.
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