The Development of Formula and Quality Control Method for Farnesol Beauty Hydrogel Patch

• Main Authors: Chun-Hsing Li, 李俊興
• Other Authors: Ce-Shing Sheu
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/37580180112095473339

碩士 === 朝陽科技大學 === 應用化學系碩士班 === 100 === Recently, the additive of skin care products has been gradually changed. Since Air pollution, overusing air-conditioner, ozone hole, ultraviolet radiation and tense, fast-paced lifestyle have caused the skin damage and unhealthy. The content of skin care products need to change to respond the environmental variation. Lately, cosmetic scientist found that farnesol is a relatively good ingredient in skin health. In the research, a gas chromatography method was developed to determine the content and stability of farnesol in beauty hydrogel patch. The VA-1 type column made by Varian company is using and carrier gas is nitrogen. The injection temperature: 250 ℃, FID detection temperature: 280 ℃, split: 1: 50, flow rate at a linear velocity of 12.66 psi, an injection volume: 1 μL. The oven temperature was programmed from 80 ℃ held for 0 min , then 10 ℃/min ramp to 130 ℃, then 100 ℃/min ramp to 260 ℃ held for 3.5 min. Total run time was 10 min. In the analytical method validation of farnesol in beauty hydrogel patch, the results of relative standard deviation are between 0.797 % and 1.6691 %; the results of recovery are between 95.1 % and 104.2 %; the result of linear regression coefficient is 0.9997; the result of limit of detection is 2 ppm; the result of limit of quantification is 7 ppm. In the stability tests, farnesol beauty hydrogel patch was placed in the room temperature condition (25 ± 2 ℃) and the accelerated condition (40 ± 2 ℃) for six-month stability test. The appearance of product did not significantly change and the content of farnesol was declined to 92.78 ％ in the room temperature test and declined to 88.01 ％ in the accelerated test at the six month.