Efficient Synthesis of Fused Triazolo[4,5-d]quinoline Derivatives via Palladium Catalysis Mediated by Tetrabutylammonium Iodide

碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 100 === In Recent years, the vast number of pharmaceutical drugs and natural products that contain triazole ring system with substituents at 1, 4- position,proven to have an enhanced medicinal properties such as anti-HIV, antimicrobial, anti-inflammatory, anticonvuls...

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Main Authors:	Cheng-Hao Yang, 楊政澔
Other Authors:	Jeh-Jeng Wang
Format:	Others
Language:	zh-TW
Published:	2012
Online Access:	http://ndltd.ncl.edu.tw/handle/75051453131288225970

id	ndltd-TW-100KMC05537017
record_format	oai_dc
spelling	ndltd-TW-100KMC055370172015-10-13T21:55:42Z http://ndltd.ncl.edu.tw/handle/75051453131288225970 Efficient Synthesis of Fused Triazolo[4,5-d]quinoline Derivatives via Palladium Catalysis Mediated by Tetrabutylammonium Iodide 利用TBAI為媒介與鈀金屬去催化合成Triazolo[4,5-d]quinoline之衍生物 Cheng-Hao Yang 楊政澔碩士高雄醫學大學醫藥暨應用化學研究所 100 In Recent years, the vast number of pharmaceutical drugs and natural products that contain triazole ring system with substituents at 1, 4- position,proven to have an enhanced medicinal properties such as anti-HIV, antimicrobial, anti-inflammatory, anticonvulsant, anticancer and antifungal. Quinoline used in the treatment of malaria, and their antibacterial, anti-inflammatory, anti-tumours activity were proved recently. In this thesis, we report the synthesis of triazolo-quinoline/ chromene/ thiochromene via CuAAC and intramolecular electrophilic cyclization by 5 steps. And the total yield can achieve 24~38%. In order to improve the yield, we developed an efficient 3 steps methodology to synthesize our triazole derivatives with an increased total yield (45~56%), whereas earlier reported yield was about 24~38% and in 5 steps. Jeh-Jeng Wang 王志鉦 2012 學位論文 ; thesis 131 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 100 === In Recent years, the vast number of pharmaceutical drugs and natural products that contain triazole ring system with substituents at 1, 4- position,proven to have an enhanced medicinal properties such as anti-HIV, antimicrobial, anti-inflammatory, anticonvulsant, anticancer and antifungal. Quinoline used in the treatment of malaria, and their antibacterial, anti-inflammatory, anti-tumours activity were proved recently. In this thesis, we report the synthesis of triazolo-quinoline/ chromene/ thiochromene via CuAAC and intramolecular electrophilic cyclization by 5 steps. And the total yield can achieve 24~38%. In order to improve the yield, we developed an efficient 3 steps methodology to synthesize our triazole derivatives with an increased total yield (45~56%), whereas earlier reported yield was about 24~38% and in 5 steps.
author2	Jeh-Jeng Wang
author_facet	Jeh-Jeng Wang Cheng-Hao Yang 楊政澔
author	Cheng-Hao Yang 楊政澔
spellingShingle	Cheng-Hao Yang 楊政澔 Efficient Synthesis of Fused Triazolo[4,5-d]quinoline Derivatives via Palladium Catalysis Mediated by Tetrabutylammonium Iodide
author_sort	Cheng-Hao Yang
title	Efficient Synthesis of Fused Triazolo[4,5-d]quinoline Derivatives via Palladium Catalysis Mediated by Tetrabutylammonium Iodide
title_short	Efficient Synthesis of Fused Triazolo[4,5-d]quinoline Derivatives via Palladium Catalysis Mediated by Tetrabutylammonium Iodide
title_full	Efficient Synthesis of Fused Triazolo[4,5-d]quinoline Derivatives via Palladium Catalysis Mediated by Tetrabutylammonium Iodide
title_fullStr	Efficient Synthesis of Fused Triazolo[4,5-d]quinoline Derivatives via Palladium Catalysis Mediated by Tetrabutylammonium Iodide
title_full_unstemmed	Efficient Synthesis of Fused Triazolo[4,5-d]quinoline Derivatives via Palladium Catalysis Mediated by Tetrabutylammonium Iodide
title_sort	efficient synthesis of fused triazolo[4,5-d]quinoline derivatives via palladium catalysis mediated by tetrabutylammonium iodide
publishDate	2012
url	http://ndltd.ncl.edu.tw/handle/75051453131288225970
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Efficient Synthesis of Fused Triazolo[4,5-d]quinoline Derivatives via Palladium Catalysis Mediated by Tetrabutylammonium Iodide

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