| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所碩士在職專班 === 100 === Purpose:
Occlusion of permcath is the major problem in long-term care of end stage renal disease patients. Thrombolytic therapy is an option to treat occlusion of permcath, but comparison with different modalities of administration would be warranted.
Methods:
A retrospective cohort study was conducted at Kaohsiung Armed Forces General Hospital from January 1st, 2004 to December 31st, 2010. The patients who suffered from occlusion of permcath at least 1 week after indwelling permcath were enrolled into the study. Anyone who underwent urokinase 250,000 iu transcatheter infusion for 24 hours was enrolled to our study. The patient’s general data, results of patency and duration of primary patency were reviewed.
Results:
1,314 permcath were inserted for our hemodialysis service from 2004 to 2010. 82 of these catheters developed total thrombosis during this time and urokinase was used to restore patency one or more times – total 61 treatments. The permcaths could be recanalized after thrombolytic therapy and the primary patency was 241.3±218.8 (8-891) days; the secondary patency was 122.4±166.6 (15-610) days. No bleeding adverse events occurred.
Conclusion:
Transcatheter infusion for 24 hours with urokinase 250,000 iu via permcath is an acceptable option of permcath care.
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