| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所 === 100 === Coenzyme Q10, CoQ10, had several pharmacological activities, including antioxidant, improvement of cardiac bioenergetics, enhancing the immune system. However, CoQ10 was insoluble in water and low bioavailability. This study aimed to develop dripping pills of CoQ10 with high aqueous solubility, dissolution rate and bioavailability.
By 23 factorial designs, CoQ10 dripping pills were prepared by CoQ10, poloxamer 407 as surfactant and oil type (olive oil or capryol 90) as oil base. The physicochemical properties of each formulation were characterized by solubility test, dissolution test, weight variation test, scanning electron microscope (SEM) and differential scanning calorimetry (DSC). The pharmacokinetic study of CoQ10 dripping pills (60 mg/kg), in comparison to a powder of CoQ10 (1000 mg/kg), was also carried out in rabbits after a single oral dose.
CoQ10 dripping pills formulation exhibited high solubility (70.88 μg/ml) and 22-fold high release percentage than the powder CoQ10. In all CoQ10 dripping pills formulations, CoQ10 existed mainly as an amorphous form as determined by DSC. In the pharmacokinetics study, CoQ10 dripping pills showed 101-fold high bioavailability than powder.
|
|---|
