| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所 === 100 === The study aims to evaluate the pharmacokinetic differences of
bioactive constituents between commercial extract and traditional
decoction of Ge-Gen Tang, Shu-Ching-Huo-Hsieh Tang and
Shao-Yao-Gan-Cao Tang. The rapid and sensitive quantitative
methods for glycyrrhizin and paeoniflorin in plasma samples are
developed and validated by using HPLC.
After oral administration of Ge-Gen Tang, Shu-Ching-Huo-Hsieh
Tang and Shao-Yao-Gan-Cao Tang, the plasma levels-time profiles
of glycyrrhizin were adequately described by an one-compartment
model.
The results showed that after oral administration of commercial
extract in New Zealand rabbit, the AUC 0-∞, C max is significantly
larger than traditional decoction in GT (AUC 0-∞: 49.28 ± 16.9 and
17.89 ± 2.01; C max : 3.61 ± 0.25 μg/ml and 1.24 ± 0.16 μg/ml), the
T max in decoction was shorter than commercial extract of SYGCT
(T max 6.89 hr and 10.94 hr), and after oral administration SCHACHT
showing same result. The T max of traditional decoction was 7.08 hr
and of commercial extract was 8.30 hr.
So the pharmacokinetic results are useful for quality control and
clinical pharmacokinetic studies of commercial extracts and
traditional decoctions of GT, SCHHT and SYGCT.
|
|---|
