Study of Melamine Exposure with Urinary Microalbumin Concentration in School Children

• Main Authors: Yi-Ling Chen, 陳宜伶
• Other Authors: Ming-Tsang Wu
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/38348845485413351389

碩士 === 高雄醫學大學 === 職業安全衛生研究所 === 100 === Abstract The outbreak of melamine-tainted infant formula has raised concerns about causing kidney stones and severe kidney problems in young children worldwide. Recently, epidemiological studies show that exposure to low doses of melamine increased the risk of adult urinary tract stones. To date there is limited data regarding the effects of low doses of melamine exposure and children''s health. Melamine, a widely used chemical found in many daily use products, i.e., daily life utensils, cutlery, plastic, adhesive and paint toys, which may be the sources of the presence of urinary melamine. However, it is not known whether exposure to melmaine in our daily life might cause kidney problems in children. In most of the studies in this incident, they use renal ultrasonography to screen stone type and further cross checked by radiologist. For the kidney function assessment, in addition to the blood measurement, non-invasive urine measurement is more convenience. However, most of the studies use random urine to measure melamine exposure and clinical measurement of kidney function. This study was conducted 24 hour urine and random urine to creatinine ratio of urinary melmaine as melamine exposure and microalbumin as kidney function assessment among 23 children. The results show that whether urinary melamine or microalbumin, the first morning urine of two days (spot1 and spot2), and 8 hours and 24 hours had significant correlation (p<0.05); however, when we compared the urinary melamine and microalbumin in spot1, spot2, or 8 hours and 24 hours, the results show no significant correlation. The empirical results show that the random urine collection to examine melamine is feasible, preferalby in the morning to avoid the interference of the metabolism of the body factor; and for microalbumin is also varience by the water, exercise and other factors. Therefore, the reuslts should correct creatinine and then analyzed to get the true value. These data suggest that we need further study to explore the relationship between urinary melamine and microalbumin. Keywords：Melamine 、Microalbumin 、School children