Micronization of chitosan and drug encapsulation using supercritical assisted-atomization process
碩士 === 明志科技大學 === 化學工程研究所 === 100 === The chitosan (CS) and encapsulated drug particulates were prepared by a supercritical assisted-atomization (SAA) process, carbon dioxide as spraying medium and 1.2 wt% acetic acid aqueous solution as solvent. The experimental results showed that the mean size of...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2012
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| Online Access: | http://ndltd.ncl.edu.tw/handle/47000216358930698286 |
| Summary: | 碩士 === 明志科技大學 === 化學工程研究所 === 100 === The chitosan (CS) and encapsulated drug particulates were prepared by a supercritical assisted-atomization (SAA) process, carbon dioxide as spraying medium and 1.2 wt% acetic acid aqueous solution as solvent. The experimental results showed that the mean size of CS particulates increased with increasing the concentration of CS solution, higher saturator temperature was favor to small particulates. And the optimal flow ratio of carbon dioxide to CS solution was 1.8. The model drug of encapsulated drug particulates is theophylline (TPH). Encapsulated drug particulates were prepared from co-precipitatuon of SAA process with the above optimal condition of SAA process. The effect of different mass ratio of CS to TPH (Z = CS/TPH) on dissolution test of the encapsulated drug particulates was investigated in this study. According the experimental results of XRD and DSC, the crystal form of SAA treated TPH from as-received TPH was unchanged. FTIR spectra of encapsulated drug particulates indicated that an intermolecular hydrogen bond had formed between the carbonyl group of TPH and amide group of CS. In vitro release of TPH from encapsulated drug particulates showed the dissolution rates were retarded. The different dissolution rate of TPH drug could be manipulated by various mass ratios during the SAA process.
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