Simultaneous Encapsulation of Oil-soluble and Water-soluble Drugs in Catanionic Vesicles

• Main Authors: Wen-YuChiu, 邱文昱
• Other Authors: Yu-Min Yang
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/60633493155950633020

碩士 === 國立成功大學 === 化學工程學系碩博士班 === 100 === Three catanionic surfactants (DeTMA-TS , DeTMA-DS and DTMA-DS) can be made by precipitation . Catanionic vesicles can be prepared with 20v/v% ethanol by the semi-spontaneous process. A study can be tested the effects of cholesterol concentrations on the size, zeta-potential, PDI ,and physical stability in 20v/v% ethanol solution. The catansomes were used to solubilize oil-soluble drug such as vitamin E acetate and encapsulate water-soluble drug such as arbutin to test oil-soluble drug , water-soluble drug and simultaneous encapsulation on encapsulation behavior , membrane rigidity and release behavior . In addition, because structure of vitamin E acetate is similar to cholesterol , a study if vitamin E acetate act as stabilizer as cholesterol is deserved to research. The experimental results reveal cholesterol can stabilize the vesicle, especially for 6mM. For drugs encapsulated catansome system, vitamin E acetate seems to act as stabilizer as cholesterol to let vesicle stable. On the contrary, arbutin can damage the stability of vesicle because it damage the attration force between head groups. As for encapsulation of oil-soluble drug , encapsulation efficiency of oil-soluble drug increased with the decrease of membrane fluidity because membrane is more hydrophobic. As for encapsulation of water-soluble drug , encapsulation efficiency of water-soluble drug increased with the increase of vesicle size due to the core volume. In addition, encapsulation efficiency of water-soluble drug increased with the decrease of membrane fluidity due to membrane permeability. Release rate of water-soluble drugs decreased with the decrease of membrane fluidity. What’s more, vitamin E acetate can stabilize vesicles without cholesterol. Therefore, vitamin E acetate can be not only encapsulater drug , but also the stabilizer.