The liquid/powder ratio effect on properties of calcium phosphate/calcium composite bone cement (I)

• Main Authors: Wei-MinHsiao, 蕭瑋民
• Other Authors: Jiin-Huey Chern Lin
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/71056974111399110764

碩士 === 國立成功大學 === 材料科學及工程學系碩博士班 === 100 === Calcium phosphate cement has excellent biocompatibility and adequate mechanical properties. Also, it has good osteoconductivity but has slow resorption rate in the human body. Calcium sulfate has excellent biocompatibility and fast resorption rate in human body. When calcium sulfate dissolved, the calcium ions were released which provided osteoinductivity. The resorbed calcium sulfate can be used as materials of bone matrix. Upon degrading it also generates pores which makes the newly formed bone integrate into the implant along with the pores and contacts. This research studies the effect of calcium phosphate bone cement liquid-powder ratio on injectability of the pastes. In vitro tests of both short and long term mechanical property tests and other physical properties tests were performed. Results show that CM1 and CM2 were able to improve the injectability of the paste. This formula can even be injected through 30 cm tubes and maintained form without disintegrating. Furthermore, increasing the liquid-powder ratio increases porosity and degradation rates, which helps cell growth and attachment. Finally, testing of applicable liquid-powder ratio in different material properties for clinical purposes was performed.