The molecular mechanism of G-CSF-induced stem cell mobilization in Alzheimer’s disease mouse model

• Main Authors: Yi-RuGu, 辜羿茹
• Other Authors: Kuen-Jer Tsai
• Format: Others
• Language: en_US
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/96801927548808841821

碩士 === 國立成功大學 === 臨床醫學研究所 === 100 === Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor named for its role in the proliferation and differentiation of bone marrow stem cells (BMSCs). Administration of G-CSF mobilized the BMSCs from bone marrow into the peripheral blood. In our previous studies, we found that G-CSF could induce stem cells release from the bone marrow, stimulate neurogenesis surrounding the amyloid β (Aβ) plaques in mouse brain, and it significantly improve the neurological function of the Alzheimer’s disease (AD) mice. Previous publications showed that G-CSF-induced BMSCs migration could rescue the CNS injury and AD. Recently, G-CSF had even been used in stroke models, because it could induce neurogenesis near the damage area. But the mechanism of G-CSF-mediated migration of bone marrow-derived cells into CNS is still an open question. In this thesis, I want to evaluate whether G-CSF could promote the mobilization and migration of BMSCs into the brain damaged areas and the recovery of cognitive function in the AD mouse model.