Study of palladium-catalyzed arylsulfonation of alkynes

• Main Authors: Chan, Fu-Wei, 詹富為
• Other Authors: Chuang, Shih-Ching
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/75880968021325058850

碩士 === 國立交通大學 === 應用化學系碩博士班 === 100 === In this thesis, we investigated the coupling reaction between sulfonic acid and terminal alkynes resulting vinyl sulfonates compounds by using Pd(OAc)2 as catalyst. In this content, we also optimized the reaction conditions and discussed the reactivity of different functional groups as starting material. To characterize these vinyl sulfonates derivatives, we took advantage of NMR, IR, MS and X-ray diffraction. After identifing these structure, we used them to perform Sonogashira coupling reaction and found that this reaction can tolerate a variety of alkynes to form different substituted enynes.