Studies on the Chemical Constituents from the Formosan Gorgonian Coral Menella sp.

• Main Authors: Shih-Yao Kao, 高詩堯
• Other Authors: Ping-Jyun Sung
• Format: Others
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/x96mwt

碩士 === 國立東華大學 === 海洋生物科技研究所 === 100 === In the further studies on the chemical constituents of a gorgonian Menella sp. collected off the waters of Taiwan, six new sesquiterpenoids, including menelloides A–D (1–4), (+)-chloranthalactone B (5), and (–)-hydroxylindestrenolide (6), along with three known compounds seco-germacrane anhydride (7), 3'-O-acetylthymidine (8), and cholesterol (9) were isolated. The structures of compounds 1–9 were established by spectroscopic methods and by comparison of the spectroscopic data with those of related metabolites, and sesquiterpenoid 1 was found to possess a new carbon skeleton. Metabolites 1, 5, 6 and 8 displayed inhibitory effects on the generation of superoxide anion by human neutrophils, and metabolites 4 and 8 showed weak inhibitory effects on the elastase release by human neutrophils at a concentration of 10 ug/mL.