Synthesis And Characterization Of 3-Substituted Coumarine Derivatives

• Main Authors: Shih-long Chiu, 邱世龍
• Other Authors: Yuh-wen Ho
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/90783774671413130935

碩士 === 桃園創新技術學院 === 材料應用科技研究所 === 100 === Cyclocondensation reaction of appropriate salicylaldehydes with acetoacetic ethyl acid in the presence of piperidine to yield the corresponding substituted 3-acety-comarine derivatives, which condensed with DMFDMA in the presence of toluene afforded the corresponding 3-(3-dimethylamino-acryloyl)-coumarine derivatives. On the other hand, a series of novel 3-[7-substituted-8-(4-substituted-phenyl)azo-pyrazol[1,5- a]pyrimidine]-coumarines were also obtained by the intramolecular cyclization of 3-(3-dimethylamino-acryloyl)-comarine derivatives with appropriate 3-substituted-5-amino-4-(4-substituted -phenyl)azo-pyrazoles under acid conditions. The structures were characterized by IR, 1H NMR, mass and elemental analysis. The absorption spectra characteristics were investigated in DMF and dichloromethane by UV-vis absorption.