Development of Sodium Alginate, Carrageenan, Chitosan and Calcium Chloride in the Matrix Control Release Tablet

• Main Authors: Shu-Hua Yu, 游淑華
• Other Authors: Deng-Fwu Hwang
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/96576812870701236585

碩士 === 國立臺灣海洋大學 === 食品科學系 === 100 === This study is to use hydrophilic polymers (sodium alginate and carrageenan) and crosslink agents (calcium chloride and chitosan) to crosslinking reaction. When the tablets were dissolved with water, surface gel was performed and showed drug sustained release. The differential scanning calorimetry analyzer proved no mutual effect between excipients and acetaminophen. To prepare hydrogel matrix sustained release, tablets containing acetaminophen with alginate, carrageenan and chitosan were as the matrix material. The optimal formulation was examined by using in vitro dissolution test and UV spectrophotometer test. The result showed that the test ratio of drug sustained release sodium alginate, carrageenan and crosslink agents (calcium chloride and chitosan) 1:1:1:1 which had up to 20-24 hr. After amplification of process, the powder characteristics were as follows: angle of repose, 42 degrees; crude density, 0.41 g/cm3; tapped density, 0.46 g/cm3; the water content, 3.59%; and the powder content, 98.21 ± 0.95%. Each tablet was 250.54 ± 0.59 mg, containing main components 120 mg, and the average thickness was 4.63 mm, and the hardness was 80.5 N. The content of tablets tested by high performance liquid chromatography method was 99.07 ± 0.97%, the content uniformity for each tablet was 97.10 ± 1.17%. In vitro dissolution in 0.1 N HCl, pH 4.5 phosphate buffer solution and pH 6.8 phosphate buffer solution, the complete release of content was 24 hr, 22 hr and 20 hr.