Measurements of Nano Particles’Brownian Motion near the Boundary in a High Concentration Solution
碩士 === 國立臺灣大學 === 應用力學研究所 === 100 === A quantitative immunosensing technique based on the measurement of nanoparticles’ Brownian motion is one of newly innovative bio-sensor chip on miniaturized devices and still in developing. There are some advantages of the technique such as highly compatible to...
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ndltd-TW-100NTU054990572015-10-13T21:50:18Z http://ndltd.ncl.edu.tw/handle/09102979916101454152 Measurements of Nano Particles’Brownian Motion near the Boundary in a High Concentration Solution 量測邊界層附近高濃度奈米粒子之布朗運動 Jen-Chieh Lu 呂仁傑 碩士 國立臺灣大學 應用力學研究所 100 A quantitative immunosensing technique based on the measurement of nanoparticles’ Brownian motion is one of newly innovative bio-sensor chip on miniaturized devices and still in developing. There are some advantages of the technique such as highly compatible to any lab-on-chip device and easily fabricated without micro-electro-mechanical-system (MEMS) process. However, there are still some physical phenomena needed to research in order to optimize this technique. Boundary effect can no more be neglected in a micro system, therefore; this study aims to investigate Brownian motion behaviors in the micro channel, which combines effects of high concentrated nanoparticles, surface modification, different size of nanoparticles and very closed to boundary. The sizes of particles are chosen by simulating real virus and anti-virus. The measurements and analysis of Brownian motion are primarily set up by using micro Particle-Tracking-Velocimetry (μ-PTV) and secondly set up by Fluorescent Correlation Spectroscopy (FCS). By the velocity profiles, it could be easily found out that Brownian motion present as Gaussian distribution; still, Brownian velocity can be obtained by calculating the standard deviation of particles’ velocity. Another secondly method of measurement Brownian motion is FCS which records the intensity signal of particles and analyzes by autocorrelation function which measures the self-similarity of a time signal and obtains the diffusion coefficient. Whatever analyzed methods be used, the results present that Brownian motion gets slow when the particles close to the boundary due to the boundary effect and no slip condition. The radius of particles is proportional to inversely square Brownian velocity. As concentration of solution gets larger, the effective viscosity of solution gets larger, which makes the Brownian motion becomes slower. Surface modification makes the surface become hydrophobic, and Brownian motion is measured comparing with hydrophilic but the there is no apparently different Brownian velocity between two surfaces. Finally, as smart phone with high pixels camera become popular, analysis program could be written as application, therefore; this innovative technique can be bring into the daily life. Horn-Jiunn Sheen 沈弘俊 2012 學位論文 ; thesis 73 zh-TW |
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碩士 === 國立臺灣大學 === 應用力學研究所 === 100 === A quantitative immunosensing technique based on the measurement of nanoparticles’ Brownian motion is one of newly innovative bio-sensor chip on miniaturized devices and still in developing. There are some advantages of the technique such as highly compatible to any lab-on-chip device and easily fabricated without micro-electro-mechanical-system (MEMS) process. However, there are still some physical phenomena needed to research in order to optimize this technique. Boundary effect can no more be neglected in a micro system, therefore; this study aims to investigate Brownian motion behaviors in the micro channel, which combines effects of high concentrated nanoparticles, surface modification, different size of nanoparticles and very closed to boundary.
The sizes of particles are chosen by simulating real virus and anti-virus. The measurements and analysis of Brownian motion are primarily set up by using micro Particle-Tracking-Velocimetry (μ-PTV) and secondly set up by Fluorescent Correlation Spectroscopy (FCS). By the velocity profiles, it could be easily found out that Brownian motion present as Gaussian distribution; still, Brownian velocity can be obtained by calculating the standard deviation of particles’ velocity. Another secondly method of measurement Brownian motion is FCS which records the intensity signal of particles and analyzes by autocorrelation function which measures the self-similarity of a time signal and obtains the diffusion coefficient. Whatever analyzed methods be used, the results present that Brownian motion gets slow when the particles close to the boundary due to the boundary effect and no slip condition. The radius of particles is proportional to inversely square Brownian velocity. As concentration of solution gets larger, the effective viscosity of solution gets larger, which makes the Brownian motion becomes slower. Surface modification makes the surface become hydrophobic, and Brownian motion is measured comparing with hydrophilic but the there is no apparently different Brownian velocity between two surfaces. Finally, as smart phone with high pixels camera become popular, analysis program could be written as application, therefore; this innovative technique can be bring into the daily life.
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author2 |
Horn-Jiunn Sheen |
author_facet |
Horn-Jiunn Sheen Jen-Chieh Lu 呂仁傑 |
author |
Jen-Chieh Lu 呂仁傑 |
spellingShingle |
Jen-Chieh Lu 呂仁傑 Measurements of Nano Particles’Brownian Motion near the Boundary in a High Concentration Solution |
author_sort |
Jen-Chieh Lu |
title |
Measurements of Nano Particles’Brownian Motion near the Boundary in a High Concentration Solution |
title_short |
Measurements of Nano Particles’Brownian Motion near the Boundary in a High Concentration Solution |
title_full |
Measurements of Nano Particles’Brownian Motion near the Boundary in a High Concentration Solution |
title_fullStr |
Measurements of Nano Particles’Brownian Motion near the Boundary in a High Concentration Solution |
title_full_unstemmed |
Measurements of Nano Particles’Brownian Motion near the Boundary in a High Concentration Solution |
title_sort |
measurements of nano particles’brownian motion near the boundary in a high concentration solution |
publishDate |
2012 |
url |
http://ndltd.ncl.edu.tw/handle/09102979916101454152 |
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