| Summary: | 博士 === 國立陽明大學 === 醫學工程研究所 === 100 === Cadium selium quantum dots (CdSe QDs) with their unique optical properties and have been applied for medical bio-labeling and bio-imaging. It is well documented that the optical property of CdSe QDs is influenced by its size which is in turn controlled by crystal growth. In theis study, a material of multi-walled carbon nanotubes (MWCNTs) was chosen as a template for growing CdSe crystal to obtain QDs of small size. Our results indicate that CdSe QDs were successfully formed on the carbon nanotube. We found that the MWCNT/CdSe nanocomposites synthesized from precursor solution at different pH are not significantly different. However, the average particle size of CdSe QDs can be decreased by shortening the reaction time and the resulted CdSe QDs emit green light.
CdSe QDs without surface modification have been shown toxic to cells. To improve the biocompatibility and in the meantime to obtain theranostic nanoparticles, the CdSe QDs were encapsulated with magnetic hydroxyapatite by a co-precipitation method. These synthesized dual-functional nanoparticles are needle-like with an average grain size of about 300 × 10 nm. These nanoparticles are photostable and superparamagnetic capable of generating heat rapidly in an AC magnetic filed. When present in cell culture medium, the nanoparticles can be uptaken by HFL1 cells and A549 cells within 3 days. The nanoparticles are biocompatible and can been applied for hyperthermia. We believe that the developed nanoparticles could be used for hyperthermia and bio-imaging as theranostic nanoparticles.
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