| Summary: | 碩士 === 國立陽明大學 === 醫學工程研究所 === 100 === The aim of this research was to develop a contrast agent with ultrasound (US) and magnetic resonance (MR) imaging contrast with ultrasonically triggered drug release behavior. The novel magnetic drug-loaded microbubble was composed of lipophilic superparamagnetic iron oxide (SPIO) nanoparticles and amphipathic polymer (CHC) through hydrophobic interaction. The size of CHC magnetic microbubbles is about 2.5 μm, and the structure of the microbubbles was analyzed by using transition electronic microscope (TEM) and X ray diffraction (XRD). It could be clear seen the (311) plane of iron oxide. In addition, measurement of magnetizations behavior of magnetite CHC magnetic microbubbles, no hysteretic loops existed and the microbubbles are superparamagnetic. In this study it was found that a hydrophobic agent was encapsulated within bubble shell, and superparamagnetic iron oxide nanoparticles could enhance the stability and drug encapsulation. According to cell viability test, the drug encapsulated in the CHC magnetic microbubbles could be released after therapeutic ultrasound (1 MHz) triggering so that induced cell death. Furthermore, in vitro/ in vivo imaging experiments confirmed that the novel drug vehicle exhibited magnetic resonance and ultrasound imaging functionality.
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