The Relationship between the Type 2 Diabetes Mellitus and Colorectal Cancer in Taiwan

• Main Authors: Pei-Chin, Chen, 陳珮菁
• Other Authors: Wei-Pin, Chang
• Format: Others
• Language: zh-TW
• Online Access: http://ndltd.ncl.edu.tw/handle/rxnfsn

碩士 === 元培科技大學 === 健康產業管理研究所 === 100 === Recently, some researches indicated that the incidences of colorectal cancers would be significantly increased in diabetes as compared with non-diabetes population. In fact, the mechanism(s) to increase the incidence of colorectal cancer in T2DM is still uncertain. This study elucidated the relationship between colorectal cancer and T2DM based on the national health insurance research database from the Bureau of National Health Insurance (BNHI) in Taiwan. From Jan. 2002 to Dec. 2003, 6381 newly diagnosed T2DM beneficiaries with age over 50 (female/male: 3182/3199) were randomly and cumulatively recruited in the study. Meanwhile, 19122 non-diabetes beneficiaries (female/male: 9533/9589), age and sex matched, were also enrolled in a parallel fashion for comparison. All the study participants had been followed up to the end of year 2008. The Cox proportional hazard regression was used to analyze the risk of colorectal cancer in T2DM. There was statistically no significant difference of incidence of colorectal cancer between participants with T2DM and non-diabetes counterpart after adjusting the confounding factors (HR=1.142, P=0.185). Additionally, as gender factor putting into consideration, however there was significantly higher risk of colorectal cancer in male T2DM (HR=1.286, P=0.047) but not in female T2DM (HR=1.116, P=0.477). Furthermore, as far as the colon cancer was concerned specifically, the incidence of colon cancer was no significantly difference in T2DM as compared with non-diabetes counterpart (HR=1.220, P=0.077). Again, the risk of colon cancer was higher in male T2DM (HR=1.346, P=0.042) but not in female. The abovementioned, parallel, cross-sectional and population-based results clearly suggested that the incidence of colorectal and colon cancers were significantly greater in T2DM male population.