| Summary: | 碩士 === 國立中正大學 === 化學工程研究所 === 101 === Liver is one of the important human organs in metabolism. Hepatocytes perform most of physiological liver function including metabolize of proteins and lipids, synthesis of plasma proteins and bile, storage of glycogen. The mitochondria of hepatocytes is main place to product ATP through TCA cycle and electron transfer chain to provide the require energy of human body
This research use the human hepatocyte metabolic network HepatoNet1 to accomplish physiological objective in degradation LDL, HDL and formation of glycocholic acid under the condition of uptaking importable nutrients (e.q. oxygen, water, essential amino and fatty acids, vitamins) and secretion non-degradable end products of hepatic metabolism, for example,CO2 and urea.
We use Flux balance analysis to simulate at the situation of perturbations and get flux distribution of network at steady state. We compare the result of perturbations to the fluxes of normal condition, then getting the fluxes with significant difference, therefore finding out the reactions which could not carry flux would cause some failures of physiological functions and the corresponding Enzyme Deficiencies.
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