LPS-Induced Episodic-Like Memory Deficits in Wistar Rats as Animal Model for Early Stage of Neuroinflammation

• Main Authors: Min Huang, 黃旻
• Other Authors: Jay-Shake Li
• Format: Others
• Language: en_US
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/59553492650163130677

碩士 === 國立中正大學 === 心理學研究所 === 101 === Episodic Memory is the memory of an event from personal experience. It is the integration of what was the event, where was the event occurred, and when was the event happened. Previous researches demonstrated that episodic memory lost is one of the very early signs of neuroinflammation, such as, Alzheimer’s diseases. For the past decades many well-established neuroinflammation animal models mimicked pathological changes observed in Alzheimer’s diseases. However, memory assessments for these animal models were limited. To our best knowledge, most neuroinflammation studies were conducted with spatial memory tasks, particularly, the Morris Water Maze. In order to establish an early stage of neuroinflammation that express the early signature signs of diseases, an animal model with episodic memory deficits is required. We induced a globalized neuroinflammation by injecting a low dose of lipopolysaccharide (LPS) into the lateral ventricle. The injections were conducted in acute fashion (100 μg) and subacute fashion (20 μg/ time/day, 5 times). Four object recognition paradigms were carried out to evaluate all memory. The results from both of the LPS administered groups revealed deterioration of episodic-like memory. Three basic memories remained intact in acute injection group, but partially impaired in subacute injection group. Furthermore, accumulation of activated microglia was observed in hippocampus of LPS treatment groups. The LPS-induced animal model may be applied in further developing of better detections and treatments of early stage of neuroinflammations.