The association of KLF8 expression with the clinical parameters of oral cancer

• Main Authors: Zong-Hong Cai, 蔡宗宏
• Other Authors: 許立松
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/90840608339860956006

碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 101 === Oral carcinoma is one of the most common malignant neoplasms in Taiwan, Several possible risk factors could cause oral cancer including smoking, drinking, chewing betel nuts and the relevance is increasing year by year. The tumorogenesis of oral carcinoma is well known, but the genetic alternations and mechanisms of metastasis of oral carcinoma are largely unknown. Krüppel-like factor 8 (KLF8) is a transcription factor belonged to the Krüppel-like factor (KLF) family. KLF8 plays a key role in oncogenic transformation and highly overexpressed in several types of invasive human cancer. To evaluate the biological role of KLF8 in oral cancer, We have conducted immunochemistry stain (IHC) using tissue microarray with 298 oral cancer samples. Base on chi square test, KLF8 expression was not associated with the patients’ age, gender, tumor size, and survival. Using Kaplan-Meier analysis also revealed that no significant overall survival rate in patients with or without KLF8 expression. Our results provided the expression of KLF8 in oral cancer and suggested that KLF8 may play a minor role in oral cancer development.