The association of KLF8 expression with the clinical parameters of oral cancer
碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 101 === Oral carcinoma is one of the most common malignant neoplasms in Taiwan, Several possible risk factors could cause oral cancer including smoking, drinking, chewing betel nuts and the relevance is increasing year by year. The tumorogenesis of oral carcinoma is...
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ndltd-TW-101CSMU51070212015-10-13T22:57:21Z http://ndltd.ncl.edu.tw/handle/90840608339860956006 The association of KLF8 expression with the clinical parameters of oral cancer 第八型kruppel-like因子在口腔癌的表現模式與臨床意義 Zong-Hong Cai 蔡宗宏 碩士 中山醫學大學 生化暨生物科技研究所 101 Oral carcinoma is one of the most common malignant neoplasms in Taiwan, Several possible risk factors could cause oral cancer including smoking, drinking, chewing betel nuts and the relevance is increasing year by year. The tumorogenesis of oral carcinoma is well known, but the genetic alternations and mechanisms of metastasis of oral carcinoma are largely unknown. Krüppel-like factor 8 (KLF8) is a transcription factor belonged to the Krüppel-like factor (KLF) family. KLF8 plays a key role in oncogenic transformation and highly overexpressed in several types of invasive human cancer. To evaluate the biological role of KLF8 in oral cancer, We have conducted immunochemistry stain (IHC) using tissue microarray with 298 oral cancer samples. Base on chi square test, KLF8 expression was not associated with the patients’ age, gender, tumor size, and survival. Using Kaplan-Meier analysis also revealed that no significant overall survival rate in patients with or without KLF8 expression. Our results provided the expression of KLF8 in oral cancer and suggested that KLF8 may play a minor role in oral cancer development. 許立松 2013 學位論文 ; thesis 31 zh-TW |
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碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 101 === Oral carcinoma is one of the most common malignant neoplasms in Taiwan, Several possible risk factors could cause oral cancer including smoking, drinking, chewing betel nuts and the relevance is increasing year by year. The tumorogenesis of oral carcinoma is well known, but the genetic alternations and mechanisms of metastasis of oral carcinoma are largely unknown.
Krüppel-like factor 8 (KLF8) is a transcription factor belonged to the Krüppel-like factor (KLF) family. KLF8 plays a key role in oncogenic transformation and highly overexpressed in several types of invasive human cancer. To evaluate the biological role of KLF8 in oral cancer, We have conducted immunochemistry stain (IHC) using tissue microarray with 298 oral cancer samples. Base on chi square test, KLF8 expression was not associated with the patients’ age, gender, tumor size, and survival. Using Kaplan-Meier analysis also revealed that no significant overall survival rate in patients with or without KLF8 expression. Our results provided the expression of KLF8 in oral cancer and suggested that KLF8 may play a minor role in oral cancer development.
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author2 |
許立松 |
author_facet |
許立松 Zong-Hong Cai 蔡宗宏 |
author |
Zong-Hong Cai 蔡宗宏 |
spellingShingle |
Zong-Hong Cai 蔡宗宏 The association of KLF8 expression with the clinical parameters of oral cancer |
author_sort |
Zong-Hong Cai |
title |
The association of KLF8 expression with the clinical parameters of oral cancer |
title_short |
The association of KLF8 expression with the clinical parameters of oral cancer |
title_full |
The association of KLF8 expression with the clinical parameters of oral cancer |
title_fullStr |
The association of KLF8 expression with the clinical parameters of oral cancer |
title_full_unstemmed |
The association of KLF8 expression with the clinical parameters of oral cancer |
title_sort |
association of klf8 expression with the clinical parameters of oral cancer |
publishDate |
2013 |
url |
http://ndltd.ncl.edu.tw/handle/90840608339860956006 |
work_keys_str_mv |
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