| Summary: | 碩士 === 佛光大學 === 心理學系 === 101 === In clinic, stroke hemorrhage has been demonstrated to cause central post-stroke pain (CPSP). However, whether the learning and memory would be affected remains inconsistent. The purposes of the present study investigated whether the ventral basal complex (VBC) of thalamus-lesion induced CPSP could impair the explicit and implicit memory. The conditioned place preference (CPP) and the water maze tests were determined respectively to test the implicit and explicit memory in the current study. All rats were microinjected collagenase into the left ventricle and destroyed the VBC of thalamus to cause the central post stroke pain symptom, and then measured the CPP effect and the spatial learning effect, respectively. The present results indicated that rats with the VBC lesion would induce the CPSP effect and reflected in stronger withdrawal responses, particularly in the right leg, in Experiment 1. Experiment 2 showed that the VBC lesions facilitated the CPP and produced a resistance effect to the CPP extinction learning, on the acquisition phase. However, the VBC lesion did not affect the spatial learning in water maze task. The present findings might imply that the VBC lesion-induced CPSP can affect the implicit memory but not the explicit memory. The data can provide some implications in clinic.
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