| Summary: | 博士 === 義守大學 === 材料科學與工程學系 === 101 === The properties of metallic glasses emphasize relatively good thermal stability, an extremely wide supercooled liquid region, homogeneous distribution of multiple elements, ease of fabrication, high tensile strength, high elastic modulus and high corrosion resistance. The thin film metallic glasses have a great potential for applications in the health-care systems.
Microbes are including virus, bacteria, fungus and rickettsia. The virus, fungus or bacteria harboring flagellum, fimbriae or hyphae are difficulty in vision. The cell walls or membranes with lipopolysaccharide, peptidoglycan, teichoic acid, proteins, chitin, glucan, phospholipids including adhesins are interacted with surface of materials as climbing the mountain to save the microorganisms’ life.
The growth requirements of microorganisms demand chemical ones as carbon, oxygen, nitrogen; and physical ones as temperature, osmotic pressure, pH, or humidity. After the adhesion of bacteria to a biomaterial surface, the microorganisms have the opportunity in developing the biofilms to resist human’s defense and get virulence.
The impact is quantitative microbial counts during the microbes- TFMGs interactions to get the time-serial growth curve and to prepare the aseptic specimens without temperature or vibration interference, and without taking picture’s bias. What period is the best one in interactions on microbes-materials? In experiment, it is necessary to place microbes about 3 hours onto the controlling substrate and test specimen within the hood technically.
Advanced biotechnology is working for quick and corrective in evaluation of cell culture, monoclonal antibodies, and molecular biology, integrated with chemistry, biology, engineering. Since the complete exploration of whole human genome sequence, the advanced technology has greatly reduced the cost of health-care information. However, the explanatory power and path to clinical translation of risk estimates for common variants reported in health-care association studies still unclear.
Advanced materials in metallic glasses are studies in electrostatic interaction or magnetic difference. Micro-nano-structural characteristics are applied for changing or increasing the affinity. To substitute the polymers, like poly-methylmethacrylate and poly-dimethylsiloxane, or stainless in health-care systems, the metallic glasses’ atoms cluster has a great potential to be integrated with other biotechnological devices for further biomedical applications.
The antibacterial effects of copper or silver are well documented in literatures. Antimicrobial effects of materials with metallic ions, Ag+ or Cu2+-exchanged, kill bacteria by destroying cell walls and membranes. But the surface of TFMGs presented the Ag+ or Cu2+ interacting with microbial cell walls or membranes? Another impact is TFMGs own the electronic or magnetic polarization for antimicrobial effects or not?
The TFMGs obtain nano-scaled surface roughness, dominant surface energy, hydrophobic with near perpendicular contact angle as the mechanisms in surface antimicrobial effects. The antimicrobial mechanisms of thin films metallic glasses (TFMGs), not like antibiotics, are physical dominantly, and chemical minor. The surface antimicrobial mechanisms of TFMGs are passive, not active.
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