Synthesis and Characterization of Vanadium(IV) NNO-Schiff Base Complexes: Their Application in DNA Photocleavage and Photocytotoxicity
碩士 === 國立中興大學 === 化學系所 === 101 === A series of vanadium(IV) complexes [V(Ln)B](ClO4)] (1d-4e) (n=1 – 4, B= dppz, d; dppn, e) have been synthesized and characterized by elemental analysis, ESI-MS, Cyclic Voltammetry and UV-Vis spectroscopy. Their activity and mechanism for photo-induced cleavage of s...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2013
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| Online Access: | http://ndltd.ncl.edu.tw/handle/52c4yu |
| Summary: | 碩士 === 國立中興大學 === 化學系所 === 101 === A series of vanadium(IV) complexes [V(Ln)B](ClO4)] (1d-4e) (n=1 – 4, B= dppz, d; dppn, e) have been synthesized and characterized by elemental analysis, ESI-MS, Cyclic Voltammetry and UV-Vis spectroscopy.
Their activity and mechanism for photo-induced cleavage of supercoiled DNA are investigated under UVA light (365 nm) and blue light (430 nm) condition. Furthermore, Photocytotoxicity assay against Ca9-22 and SCC-15 cancer cells indicate that dppn vanadium(IV) complexes (1e-4e) show significant photo-induced cytotoxicity under blue light. These results give impetus to new therapeutic strategies for developing photodynamic drugs.
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