Effect of anti-oxidant componds in HaCaT cells.

• Main Authors: Yu-Rong Hwang, 黃于容
• Other Authors: Dr.Pin-Ju Chueh
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/z25k5q

碩士 === 國立中興大學 === 生命科學院碩士在職專班 === 101 === There are two compounded whitening ingredients named ACTIWHITE LS 9808 and INDUXIN LS 9868 being used frequently in the cosmetic industry. Though their whitening function is widely evaluated, the relevant of antioxidant activity and DNA repair capacity have not been investigated. In this study , we found that Whitening Complex ACTIWHITE LS 9808 did not lead to apotheosis under a certain concentration, however it did not reduce ROS generation significantly. On the other hand, NDUXIN LS 9868 was not apoptotic under a certain concentration, however, it inhibited ROS generation with just a smidgen concentration,suggesting INDUXIN LS 9868 may prevent the oxidation and possess cell protection ability. Based on our experiment, Complex ACTIWHITE LS 9808 exhibited DNA self-repair ability,supporting by the up-regulation of phosphorylated p53. Therefore we propose that LS 9808 participate in DNA reapir in our system. In conclusion, INDUXIN LS 9868 reduces intracellular ROS generation and it may also involve in DNA repair process.