Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Among Aircraft Maintenance Workers
碩士 === 國防醫學院 === 公共衛生學研究所 === 101 === Background: Aircraft engine exhausts contain complex mixture of toxicants, including polycyclic aromatic hydrocarbons (PAHs), which may induce oxidative DNA damage. Objectives: The purpose of this study was to assess the relationships between PAHs exposure and t...
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ndltd-TW-101NDMC00580282016-03-23T04:13:27Z http://ndltd.ncl.edu.tw/handle/58866287479464998968 Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Among Aircraft Maintenance Workers 國軍飛行器發動機維修人員 多環芳香烴化合物之暴露研究 Liu, Ming-Wei 劉明威 碩士 國防醫學院 公共衛生學研究所 101 Background: Aircraft engine exhausts contain complex mixture of toxicants, including polycyclic aromatic hydrocarbons (PAHs), which may induce oxidative DNA damage. Objectives: The purpose of this study was to assess the relationships between PAHs exposure and the oxidative DNA damage among aircraft maintenance workers. Methods: We carried out a longitudinal study to evaluate the associations between PAHs exposure and the occurrence of DNA strand breaks. Exposure assessment was based on a biomarker of PAHs exposure, urinary 1-hydroxypyrene (1-OHP), and the effect was based on the percentage of DNA in tail (%T). We recruited 107 aircraft maintenance workers and categorized as exposed group and the reference group by their working characteristics. We distributed a self-administrated questionnaire to the subjects, which inquire about personal characteristics, working history and family history. Spot urine and blood samples were collected at pre-shift of the first workday and post-shift of the third workday. Statistical methods included linear regression and GEE models. Results: Urinary 1-OHP level in aircraft maintenance workers increased significantly (0.12→0.19 μg/g-creatinine) after 3 consecutive days exposure. Multivariate GEE analysis indicated that aircraft maintenance workers have elevated levels of 1-OHP than that of control group. On the other hand, the occurrence of DNA strand breaks, DNA in tail (%), of aircraft maintenance workers elevated (13.68→15.39) from pre-shift of the 1st day to post-shift of the 3rd day. Multivariate GEE analysis showed that aircraft maintenance workers had no significant increasing levels of DNA in tail (%) compared with control group. Pearson correlation analysis indicated urinary 1-OHP was not associated with DNA in tail (%). Multivariate GEE analysis demonstrated that the change of urinary 1-OHP with time didn’t affect the change of DNA in tail (%). Conclusions: Our results suggest that although DNA in tail (%) was not associated with 1-OHP to reflect oxidative DNA damage in aircraft maintenance workers, co-exposures at workplaces should be taken into consideration. Lai, Ching-Huang 賴錦皇 2013 學位論文 ; thesis 122 zh-TW |
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碩士 === 國防醫學院 === 公共衛生學研究所 === 101 === Background: Aircraft engine exhausts contain complex mixture of toxicants, including polycyclic aromatic hydrocarbons (PAHs), which may induce oxidative DNA damage.
Objectives: The purpose of this study was to assess the relationships between PAHs exposure and the oxidative DNA damage among aircraft maintenance workers.
Methods: We carried out a longitudinal study to evaluate the associations between PAHs exposure and the occurrence of DNA strand breaks. Exposure assessment was based on a biomarker of PAHs exposure, urinary 1-hydroxypyrene (1-OHP), and the effect was based on the percentage of DNA in tail (%T). We recruited 107 aircraft maintenance workers and categorized as exposed group and the reference group by their working characteristics. We distributed a self-administrated questionnaire to the subjects, which inquire about personal characteristics, working history and family history. Spot urine and blood samples were collected at pre-shift of the first workday and post-shift of the third workday. Statistical methods included linear regression and GEE models.
Results: Urinary 1-OHP level in aircraft maintenance workers increased significantly (0.12→0.19 μg/g-creatinine) after 3 consecutive days exposure. Multivariate GEE analysis indicated that aircraft maintenance workers have elevated levels of 1-OHP than that of control group. On the other hand, the occurrence of DNA strand breaks, DNA in tail (%), of aircraft maintenance workers elevated (13.68→15.39) from pre-shift of the 1st day to post-shift of the 3rd day. Multivariate GEE analysis showed that aircraft maintenance workers had no significant increasing levels of DNA in tail (%) compared with control group. Pearson correlation analysis indicated urinary 1-OHP was not associated with DNA in tail (%). Multivariate GEE analysis demonstrated that the change of urinary 1-OHP with time didn’t affect the change of DNA in tail (%).
Conclusions: Our results suggest that although DNA in tail (%) was not associated with 1-OHP to reflect oxidative DNA damage in aircraft maintenance workers, co-exposures at workplaces should be taken into consideration.
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author2 |
Lai, Ching-Huang |
author_facet |
Lai, Ching-Huang Liu, Ming-Wei 劉明威 |
author |
Liu, Ming-Wei 劉明威 |
spellingShingle |
Liu, Ming-Wei 劉明威 Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Among Aircraft Maintenance Workers |
author_sort |
Liu, Ming-Wei |
title |
Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Among Aircraft Maintenance Workers |
title_short |
Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Among Aircraft Maintenance Workers |
title_full |
Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Among Aircraft Maintenance Workers |
title_fullStr |
Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Among Aircraft Maintenance Workers |
title_full_unstemmed |
Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Among Aircraft Maintenance Workers |
title_sort |
polycyclic aromatic hydrocarbons (pahs) exposure among aircraft maintenance workers |
publishDate |
2013 |
url |
http://ndltd.ncl.edu.tw/handle/58866287479464998968 |
work_keys_str_mv |
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