| Summary: | 碩士 === 國防醫學院 === 航太及海底醫學研究所 === 101 === The report of World Health Organization in 2010 indicated that Glaucoma is one of the main causes of blindness.Glaucoma is a kind of neurodegenerative disease.Excessive intraocular pressure (IOP) caused most of glaucoma. IOP will make the retinal blood vessels are oppressed, retinal ischemia and oxidative stress overload which eventually making the retina ganglion cell apoptosis.Glucosamine(GlcN) is an endogenous amino sugar which has the ability to transfer N-acetylglucosamine(GlcNAc) to serine and threonine residues. This is a protein posttranslational glycosylation. Serine and threonine are also activation domain of protein phosphorylation.If oxidative stress signaling pathways have proteins which can be phosphorylated and glycosylated modification at the same time, glucosamine will increase glycosylated protein to reduce the level of phosphorylation and achieve the purpose of inhibiting apoptosis signals. The results of this experiment show that glucosamine not only have antioxidative property, but also downregulate pP38/ P38 level of MAPK pathway. Therefore, glucosamine can protect retinal ganglion cells from oxidative injury.
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