(1) C-H Oxidation with Hypervalent Iodine (III) at Benzylic Position without Undergoing SET(Single Electron Transfer)(2) Chemistry and Biology of Triazole-pyrrole: Click Chemistry and DNA Interaction

• Main Authors: Chun-yu Lin, 林俊佑
• Other Authors: Chi-Wi Ong
• Format: Others
• Language: en_US
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/46433024034307236604

博士 === 國立中山大學 === 化學系研究所 === 101 === There are two parts in this dissertation. Part I : benzylic C-H oxidation of methyl aromatic compounds is a useful reaction. We found that the reactive intermediate was generated by PIDA/TFA/AcOH (6:4:2) system then the reaction of methyl aromatic with the reactive intermediate could undergo benzylic C-H oxidation and studied on the mechanism via the intermediate. We anticipated this reaction without undergoing SET process. The benzylic C-H oxidation of p-methoxy toluene was effective in para electron-donating groups. Part II : we have synthesized a series of triazole-tripyrrole compound and studied on the binding affinity for duplex DNA by CT-DNA melting temperature analysis, ethidium bromide displacement assay for CT-DNA and DNase I footpring studies on HexA and HexB.