(1) C-H Oxidation with Hypervalent Iodine (III) at Benzylic Position without Undergoing SET(Single Electron Transfer)(2) Chemistry and Biology of Triazole-pyrrole: Click Chemistry and DNA Interaction
博士 === 國立中山大學 === 化學系研究所 === 101 === There are two parts in this dissertation. Part I : benzylic C-H oxidation of methyl aromatic compounds is a useful reaction. We found that the reactive intermediate was generated by PIDA/TFA/AcOH (6:4:2) system then the reaction of methyl aromatic with the reacti...
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ndltd-TW-101NSYS50650882015-10-13T22:40:48Z http://ndltd.ncl.edu.tw/handle/46433024034307236604 (1) C-H Oxidation with Hypervalent Iodine (III) at Benzylic Position without Undergoing SET(Single Electron Transfer)(2) Chemistry and Biology of Triazole-pyrrole: Click Chemistry and DNA Interaction (一)高價碘(III)試劑經由非單電子轉移的機制在苄基位置上進行C-H氧化反應(二)三唑-吡咯化合物的化學和生物學:鏈接化學和DNA的交互作用 Chun-yu Lin 林俊佑 博士 國立中山大學 化學系研究所 101 There are two parts in this dissertation. Part I : benzylic C-H oxidation of methyl aromatic compounds is a useful reaction. We found that the reactive intermediate was generated by PIDA/TFA/AcOH (6:4:2) system then the reaction of methyl aromatic with the reactive intermediate could undergo benzylic C-H oxidation and studied on the mechanism via the intermediate. We anticipated this reaction without undergoing SET process. The benzylic C-H oxidation of p-methoxy toluene was effective in para electron-donating groups. Part II : we have synthesized a series of triazole-tripyrrole compound and studied on the binding affinity for duplex DNA by CT-DNA melting temperature analysis, ethidium bromide displacement assay for CT-DNA and DNase I footpring studies on HexA and HexB. Chi-Wi Ong 王志偉 2013 學位論文 ; thesis 150 en_US |
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博士 === 國立中山大學 === 化學系研究所 === 101 === There are two parts in this dissertation. Part I : benzylic C-H oxidation of methyl aromatic compounds is a useful reaction. We found that the reactive intermediate was generated by PIDA/TFA/AcOH (6:4:2) system then the reaction of methyl aromatic with the reactive intermediate could undergo benzylic C-H oxidation and studied on the mechanism via the intermediate. We anticipated this reaction without undergoing SET process. The benzylic C-H oxidation of p-methoxy toluene was effective in para electron-donating groups. Part II : we have synthesized a series of triazole-tripyrrole compound and studied on the binding affinity for duplex DNA by CT-DNA melting temperature analysis, ethidium bromide displacement assay for CT-DNA and DNase I footpring studies on HexA and HexB.
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Chi-Wi Ong |
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Chi-Wi Ong Chun-yu Lin 林俊佑 |
author |
Chun-yu Lin 林俊佑 |
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Chun-yu Lin 林俊佑 (1) C-H Oxidation with Hypervalent Iodine (III) at Benzylic Position without Undergoing SET(Single Electron Transfer)(2) Chemistry and Biology of Triazole-pyrrole: Click Chemistry and DNA Interaction |
author_sort |
Chun-yu Lin |
title |
(1) C-H Oxidation with Hypervalent Iodine (III) at Benzylic Position without Undergoing SET(Single Electron Transfer)(2) Chemistry and Biology of Triazole-pyrrole: Click Chemistry and DNA Interaction |
title_short |
(1) C-H Oxidation with Hypervalent Iodine (III) at Benzylic Position without Undergoing SET(Single Electron Transfer)(2) Chemistry and Biology of Triazole-pyrrole: Click Chemistry and DNA Interaction |
title_full |
(1) C-H Oxidation with Hypervalent Iodine (III) at Benzylic Position without Undergoing SET(Single Electron Transfer)(2) Chemistry and Biology of Triazole-pyrrole: Click Chemistry and DNA Interaction |
title_fullStr |
(1) C-H Oxidation with Hypervalent Iodine (III) at Benzylic Position without Undergoing SET(Single Electron Transfer)(2) Chemistry and Biology of Triazole-pyrrole: Click Chemistry and DNA Interaction |
title_full_unstemmed |
(1) C-H Oxidation with Hypervalent Iodine (III) at Benzylic Position without Undergoing SET(Single Electron Transfer)(2) Chemistry and Biology of Triazole-pyrrole: Click Chemistry and DNA Interaction |
title_sort |
(1) c-h oxidation with hypervalent iodine (iii) at benzylic position without undergoing set(single electron transfer)(2) chemistry and biology of triazole-pyrrole: click chemistry and dna interaction |
publishDate |
2013 |
url |
http://ndltd.ncl.edu.tw/handle/46433024034307236604 |
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