Asymmetric Addition of Dimethylzinc to N-(P,P-Diphenylphosphinoyl) Imine Catalyzed by a Rhodium-Diene Complex toward the Synthesis of NPS-R-568
碩士 === 國立臺灣師範大學 === 化學系 === 101 === This process offers chiral arylmethylamines with a N-P,P-diphenylphosphinic protecting group from asymmetric addition of dimethylzinc to N-(P,P-diphenylphosphinoyl) imine in the presence of catalyst in situ generated from rhodium (I) and chiral diene ligand 65a, g...
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2013
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| Online Access: | http://ndltd.ncl.edu.tw/handle/25643201120917337540 |
| Summary: | 碩士 === 國立臺灣師範大學 === 化學系 === 101 === This process offers chiral arylmethylamines with a N-P,P-diphenylphosphinic protecting group from asymmetric addition of dimethylzinc to N-(P,P-diphenylphosphinoyl) imine in the presence of catalyst in situ generated from rhodium (I) and chiral diene ligand 65a, giving the 1,2-addition products in good yields and excellent enantioselectivities (ee value up to 98%) for various aldimines.
The synthetic utility of this protocol was demonstrated in the preparation of (S)-3-(2-chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl) propan-1-amine, a calcimimetic agent.
Keyword：chiral diene ligand、Rhodium、dimethylzinc、N-(P,P-diphenylphosphinoyl) imine
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