Preparation and Characterizations of Various poly (ethyl methacrylate) Microparticles Intended for a Novel Anti-fungal Tissue Conditioner

• Main Authors: Chi-chun Chou, 周啟君
• Other Authors: Chen yu-Kao
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/58574932131036966379

碩士 === 國立臺灣科技大學 === 醫學工程研究所 === 101 === Poly(ethyl methacrylate) (PEMA) and it’s copolymers are the main powder component of the tissue conditioner., a material used in the treatment of the denture-related stomatitis. Several things might affect the mechanical properties and gelation time of the tissue conditioners, including the particle size and surface properties of the PEMA particles, and adding of therapeutic agents to the tissue conditioners. In this study, various blank PEMA microparticles and intraconazole loaded PEMA microparticles were prepared by the emulsion technique. And the effect of particle size, surface morphology and properties of PEMA microparticles on its gelation time was investigated. In our study, the itraconazole-PEMA particles size range from 23.98 to 19.10 μm and are used to prepare the drug loaded tissue conditioners. And the gelation time of the drug loaded tissue conditioner is 5.28 ± 1.68 min which is the closest to the DENTSPLY Visco gel, a comericial tissue conditioner. More importantly, this drug loaded tissue conditioner could continuously release itraconazole and maintain its inhibitory effects of Candida albicans (BCRC 21538) for at least 14 days.