| Summary: | 碩士 === 東海大學 === 工業工程與經營資訊學系 === 101 === In this study, our aim was to determine the relationship between pneumococcal pneumonia (PP) and the subsequent risk for end-stage renal disease (ESRD). We conducted a population-based retrospective cohort study of 18 302 cases of PP infection diagnosed between 1998 and 2010 using claims data from the National Health Insurance Research Database (NHIRD) in Taiwan. The comparison cohort contained 73 208 age- and sex-matched patients without PP. The incidence rate ratios (IRRs) and hazard ratios (HRs) of ESRD were calculated.
The incidence rate of ESRD in the PP cohort was 2.82-fold (95% CI, 2.70-2.95) higher than that of the control cohort. The IRR of ESRD among the PP cohort members younger than 35 years of age was much greater (IRR, 10.7; 95% CI = 8.81-13.0) than that of the age-matched controls. After adjusting for age, sex, and the comorbidities, the HR of ESRD in the PP cohort was 2.03 (95% CI, 1.75-2.34, P < .001). The ESRD cumulative incidence curve showed that the PP cohort had a significantly higher risk of ESRD than the non-PP cohort (P < .001 by log-rank test).
In summary, PP is an independent risk factor for ESRD in adult patients, and the underlying pathology contributing to ESRD may be multifactorial. A long-term follow-up of renal function is recommended in adult patients following PP.
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