Applications of ankle-brachial index and pulse wave velocity in patients without clinical peripheral vascular disease

• Main Authors: Chung-Chieh Hu, 胡中傑
• Other Authors: Chin-Yin Huang
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/54496404121743571576

碩士 === 東海大學 === 工業工程與經營資訊學系 === 101 === Cardiovascular disease is a major and important board spectrum disease in Taiwan, that its total death rate exceed the one of cancer in recent years. Peripheral vascular disease is one kind of cardiovascular disease, which share the same risk factors generally. For those healthy persons who do not have clinical evidence of peripheral aterial disease, we are interested in (1) To understand the disease prevalence by measuring ankle-brachial index and pulse wave velocity (2) The relationship between these markers and risk factors of cardiovascular disease (3) The relationship between different cardiovascular outcomes and Framingham risk scoring system, and (4) The predictive value of these markers to other cardiovascular outcomes. Method: This is a cross-sectional study. From February 2008 to April 2013, we collected totally 2085 of ABI and PWV measurements at health check-up center of one Medical Center in central Taiwan. We studied the relationships between ABI, PWV and other parameters such as: demographic datas, general laboratories profile, results of MDCT, carotid songraphy and transcranial doppler.. We concluded that (1) In our study, the prevalence of peripheral artery disease related to other cardiovascular diseases is similar to previous reported, and has been summarized in the tables of Chi-square test and Mann-Whitney U test in this report, (2) Most of the traditional cardiovascular risk factors were significantly related to PWV, but not to ABI, (3) When PWV ≥ 1400cm/s, odds ratio for coronary artery disease, metabolic syndrome, carotid intima thickening, and mild carotid stenosis were 2.49, 2.97, 3.55 and 4.11 respectivetly. For a 10% 10-year risk of Framingham score, the odds ratio of PWV ≥1400 cm/s were 5.2 for men and 14.0 for women, and (4) The area under the curve under the receiver operator curve were 0.689 for coronary artery disease, 0.676 for metabolic syndrome, 0.699 for carotid intima thickening and mild stenosis with different PWV cut-off value, and corresponding 0.601, 0.613, 0.609 and 0.577 with ABI.