| Summary: | 碩士 === 國立臺北科技大學 === 化學工程研究所 === 101 === The enteric coating material coated drug controlled release technology is widely used in solid pharmaceutical, and to delay the release of drugs in the stomach so that it is released in the small intestine. Drugs coated with an enteric coating, there are three main factors:
(1) Prevent the active substance in the acidic environment of the stomach degradation
(2) To avoid contact with drugs and stomach, causing stomach bleeding and ulcers and other phenomena, prevent stomach digestive function
(3) Controlling drug release in the intestine, to achieve effective absorption
This experiment is to use the Coating pan coated on prescription drugs as the machines that will pre-coated with an enteric coating materials and medicines, first mixed into a coating solution is sprayed on the sugar pills use spray gun surface coated finish is followed by drying with hot air, it will form a film coating of pharmaceutical, during sieving to obtain adequate particle size, surface area.
Received in the 8th and the 10th standard sieve material between the controlled release dosage form enteric coating multiple layers drugs, respectively, weighed appropriate quality control different pH values (artificial gastric juice: pH = 1.2, simulated intestinal fluid: pH = 6.8 , distilled water) buffer, for three groups delayed release in vitro dissolution test, and finally the use of UV measurements controlled release dosage form of this drug release pellets situation.
The experimental results show that:
I. particles coated controlled release formulations (pellets) and Hydroxypropyl cellulose
(Hydroxypropyl cellulose; HPC) and ethyl cellulose (Ethyl cellulose; EC) such as
film-coated release after coating for pharmaceuticals effects.
II. Film-coated coated factors:
(1) The composition of the solution film coated
(2) coated with a bowl speed, the amount of coating liquid spray
(3) coating process
III. In the present study found that, for different controlled release dosage form, or
mechanism, and there are differences between the principle, but in the end be able to
achieve through the deployment of controlled prescription drugs stable release, and
to achieve long-term release of drugs effects.
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