| Summary: | 碩士 === 臺北巿立體育學院 === 運動科學研究所 === 101 === Background/Purpose: Prevalence of oxidative stress is closely associated with chronic inflammation, which leads to physiological malfunctions and diseases. Ginseng and its derivates have been reported as effective pharmacological substances against diseases. The objective of the present study was to investigate the effect of long-term Dammarane oligo-sapogenin (DS) supplementation on blood antioxidant and anti-inflammatory systems, and further evaluate the role of DS on monocyte mitochondrial activity in rats. Methods: Total forty Sprague Dawley rats were evenly divided into two groups including placebo (n=20) and DS-treated (n=20) groups, and received saline and DS substance (60 mg/kg b.w.) for 6 months respectively. Blood samples were collected from the tail vein before treatment and after 6 month DS treatment. Results: After 6 months treatment the levels of MDA (malondialdehyde) and TBARS (Thiobarbituric acid reactive substances) were significantly increased in placebo group, but in DS group were not significantly different. After 6 months treatment the SOD (superoxide dismutase) activity was significantly decreased in placebo groups, but in DS groups were not significantly different. Inflammatory markers, such as TNF-α and IL-6 were not significantly different among male rats groups. But, the levels of IL-6 were significantly decreased in female 12 month DS group than 6 month DS group. The monocyte mitochondrial activity was not significantly different among male rats groups. Conclusion: Dammarane Oligo-Saponins supplementation can prevent the increased oxidant production and oxidative damage in aged rats.
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