Chemical and Bioactive Constituents from the Stem of Astronia formosana

• Main Authors: Chin-Wei Chang, 張晉維
• Other Authors: Yu-Chang Chen
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/eg4fg2

碩士 === 中國醫藥大學 === 中國藥學暨中藥資源學系碩士班 === 102 === Astronia formosana Kanehira (Melastomataceae) is an endemic small tree distributing in the forests at altitudes of 300-500 m in the southern part of Taiwan, islands Lanyu and Lutao. The methanolic extract of the stem of A. formosana showed potent anti-inflammatory and cytotoxicity activities. The MeOH extract was partitioned into n-hexane-, ethyl acetate-, n-BuOH-, and water-soluble fractions. Bioassay-guided fractionation of active ethyl acetate-soluble fraction led to the isolation of sixteen compounds, including of four new compounds: 3,4,5,3'',4''-penta-O-methylcoruleoellagic acid (1), 3,5,3''-tri-O-methylflavellagic acid (2), 3,4,3'',4''-tetra-O-methylcoruleoellagic acid (3), and astronic acid (4), along with eleven known compounds, evofolin-A (5), farrerol (6), 5,4''-dihydroxy-7-methoxy- 6,8-di-C-methylflavanone (7), 3,4,3''-tri-O-methylellagic acid (8), 3,3''-di-O-methylellagic acid (9), 3,4,3'',4''-tetra-O-methylflavellagic acid (10), hexamethylcoruleoellagic acid (11), betulinic acid (12), arjunilic acid (13), stachilic acid (14), oleanolic acid (15), and ursolic acid (16). The structures of these compounds were elucidated by spectroscopic techniques.