The Relationship of the Occurrence of Dementia with it Comorbidity : Case - Control Study

• Main Authors: Zhao-Ting Xiao, 蕭兆廷
• Other Authors: 何文照
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/4693c4

碩士 === 中國醫藥大學 === 公共衛生學系碩士班 === 102 === Background and Purpose: Dementia has become a threat of health to people in that aging society of Taiwan. Paying more attention on the elderly or on the adult who are vulnerable at their early stage with dementia, by prevention programs can reduce their risk. This study was aimed to investigate the relationship of comorbidity of hypertension, diabetes, heart disease, hyperlipidemia, atherosclerosis, and atrial fibrillation with dementia. Whether there is gender difference or not is also the inquiry of this study. Furthermore, this study also has compared the relationship both in early-onset dementia and and late-onset dementia. Methods: This is a case-control study design. Using data sources obtained from Taiwan’s "National Health Insurance Research Database", during 2000 to 2010.The newly diagnosed patients (n=3865) with dementia (ICD-9-CM 290,3310) during 2009 to 2010 were study cases. We performed a 1:1 case-control matched analysis based on gender and age in accordance with the same database to choose control group without dementia. Conditional logistic regression analysis was used to compare the relationship of comorbidity between early-onset and late-onset dementia. This study also has adjusted the potential confounders in explanation of the relationship. Risk ratio between disease and causes is presented by odds ratio and 95% confidence intervals. VI Results: Patients with hypertension (OR=1.29, 95% CI=1.15-1.44) and diabetes (OR=1.17, 95% CI=1.04-1.31) had a higher risk of dementia than those without the above diseases. Hypertension is a dementia risk factor to men (OR=1.30, 95% CI =1.11-1.53). To female, comorbid with hypertension (OR =1.26, 95% CI =1.08-1.47) and diabetes (OR=1.21, 95% CI =1.03-1.41) were likely to have dementia in later disease phase. This study outcomes show that patients with hypertension (OR=1.82, 95% CI =1.05-3.14) and heart disease (OR =1.89, 95% CI =1.04-3.46) were significantly associated with early-onset dementia. On the other hand, hypertension (OR =1.23, 95% CI =1.09-1.38) and diabetes (OR=1.17, 95% CI =1.04-1.32 ) were both correlated to late-onset dementia. Conclusion: The results of this study found there was a higher risk of dementia after comorbidity with hypertension and diabetes. Gender effect was found in this study too. Hypertension brought more risks to men and women. Hyperlipidemia is another risk issue needed to be notified for women in the prevention of dementia. Different types of dementia had various comorbid chronic diseases is deserved more attentions for medical personnel with the competent authorities