Bisdemethoxycurcumin re-expresses of ER-α through ILK inhibition is regulated by a pathway involving Twist andYB-1 in TNBC cells
碩士 === 中國醫藥大學 === 生物科技學系碩士班 === 102 === Malignant neoplasms have continued to be the top leading cause of death. Recently, breast cancer is most common malignancy among women in Taiwan and its incidence is increasing worldwide. Triple-negative breast cancer (TNBC) accounts for approximately 20% of b...
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ndltd-TW-102CMCH51110042019-08-14T03:37:25Z http://ndltd.ncl.edu.tw/handle/x22cwt Bisdemethoxycurcumin re-expresses of ER-α through ILK inhibition is regulated by a pathway involving Twist andYB-1 in TNBC cells 二去甲氧基薑黃素透過抑制ILK下游Twist及YB-1路徑恢復三陰性乳癌細胞雌激素受體表現之研究 Chun-Chen Huang 黃俊誠 碩士 中國醫藥大學 生物科技學系碩士班 102 Malignant neoplasms have continued to be the top leading cause of death. Recently, breast cancer is most common malignancy among women in Taiwan and its incidence is increasing worldwide. Triple-negative breast cancer (TNBC) accounts for approximately 20% of breast cancer, it is defined by a lack of expression of estrogen receptor (ER), progesterone receptor (PR), and HER2. However, TNBC is a non-specific receptor expression and is therefore not suitable for use hormone therapy and target therapy,currently there is no specific clinical treatment. In this study, we used bisdemethoxycurcumin (BDMC), a natural derivative of curcumin to investigate the effects of BDMC on TNBC MDA-MB-231 cells. Interestingly, we showed that BDMC could re-express ER-α expression. Tamoxifen is one of the most widely used chemotherapeutic agents for the treatment of ER-positive breast cancer patients. Our study showed that BDMC enhanced the anticancer effect of tamoxifen through inducing apoptosis in TNBC cells.YB-1 isa known transcriptional regulator of ER-αexpression. BDMC could re-express ER-α through reducing the expression of YB-1 in TNBC cells. Moreover, we demonstrated that BDMC could decrease integrin-linkedkinase(ILK) and Twist expression that decrease expression of YB-1. These finding suggest BDMC will be a potential anticancer drug for TBNC. Tzong-Der Way 魏宗德 魏宗德 2014 學位論文 ; thesis 47 zh-TW |
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碩士 === 中國醫藥大學 === 生物科技學系碩士班 === 102 === Malignant neoplasms have continued to be the top leading cause of death. Recently, breast cancer is most common malignancy among women in Taiwan and its incidence is increasing worldwide. Triple-negative breast cancer (TNBC) accounts for approximately 20% of breast cancer, it is defined by a lack of expression of estrogen receptor (ER), progesterone receptor (PR), and HER2. However, TNBC is a non-specific receptor expression and is therefore not suitable for use hormone therapy and target therapy,currently there is no specific clinical treatment. In this study, we used bisdemethoxycurcumin (BDMC), a natural derivative of curcumin to investigate the effects of BDMC on TNBC MDA-MB-231 cells. Interestingly, we showed that BDMC could re-express ER-α expression. Tamoxifen is one of the most widely used chemotherapeutic agents for the treatment of ER-positive breast cancer patients. Our study showed that BDMC enhanced the anticancer effect of tamoxifen through inducing apoptosis in TNBC cells.YB-1 isa known transcriptional regulator of ER-αexpression. BDMC could re-express ER-α through reducing the expression of YB-1 in TNBC cells. Moreover, we demonstrated that BDMC could decrease integrin-linkedkinase(ILK) and Twist expression that decrease expression of YB-1. These finding suggest BDMC will be a potential anticancer drug for TBNC.
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author2 |
Tzong-Der Way 魏宗德 |
author_facet |
Tzong-Der Way 魏宗德 Chun-Chen Huang 黃俊誠 |
author |
Chun-Chen Huang 黃俊誠 |
spellingShingle |
Chun-Chen Huang 黃俊誠 Bisdemethoxycurcumin re-expresses of ER-α through ILK inhibition is regulated by a pathway involving Twist andYB-1 in TNBC cells |
author_sort |
Chun-Chen Huang |
title |
Bisdemethoxycurcumin re-expresses of ER-α through ILK inhibition is regulated by a pathway involving Twist andYB-1 in TNBC cells |
title_short |
Bisdemethoxycurcumin re-expresses of ER-α through ILK inhibition is regulated by a pathway involving Twist andYB-1 in TNBC cells |
title_full |
Bisdemethoxycurcumin re-expresses of ER-α through ILK inhibition is regulated by a pathway involving Twist andYB-1 in TNBC cells |
title_fullStr |
Bisdemethoxycurcumin re-expresses of ER-α through ILK inhibition is regulated by a pathway involving Twist andYB-1 in TNBC cells |
title_full_unstemmed |
Bisdemethoxycurcumin re-expresses of ER-α through ILK inhibition is regulated by a pathway involving Twist andYB-1 in TNBC cells |
title_sort |
bisdemethoxycurcumin re-expresses of er-α through ilk inhibition is regulated by a pathway involving twist andyb-1 in tnbc cells |
publishDate |
2014 |
url |
http://ndltd.ncl.edu.tw/handle/x22cwt |
work_keys_str_mv |
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