| Summary: | 碩士 === 中國醫藥大學 === 藥物化學研究所碩士班 === 102 === Epithelial-mesenchymal transition (EMT) is a progressive process in which epithelial cells take on the features of invasive mesenchymal cells. The activation of EMT has been implicated strongly associated with cancer progression. Further studies also demonstrated that the EMT processes could be activated under the hypoxia condition. The Rhodiola rosea is a traditional Chinese herb widely used as an antioxidant for treatment of hypoxia relative illness including fatigue and high altitude sickness, particularly in the area of Tibetan Plateau. Previous studies in our laboratory showed that the Rhodiola rosea ethanol extracted could significant reduced the free-radical damage, inhibited tumor migration ability and decrease MMP-2 protein activity. In this study, a purified compound, 5G, which isolated from Rhodiola rosea was evaluated and investigated the mechanisms of blocking the hypoxia-induced EMT phenomenon. Initiatory results showed that the hypoxia-inducible up-regulated HIF-1α and down-regulated E-cadherin could be partially reversed by pre-treated with 5G. The detail mechanisms which involved in EMT blockage by 5G actived in our laboratory.
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