The effects of L-carnitine supplementation on antioxidation and inflammation in patients with coronary artery disease

• Main Authors: Jun-Shuo Lin, 林君碩
• Other Authors: Ping-Ting Lin
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/39150675639667350588

碩士 === 中山醫學大學 === 營養學研究所 === 102 === High oxidative stress and chronic inflammation contribute to the pathogenesis of coronary artery disease (CAD). Cell and animals studies have shown that L-carnitine (LC) is a good antioxidant. Thus, the purpose of this study was to investigate the effects of LC supplementation (1000 mg/d) on anti-oxidation and anti-inflammation in patients with CAD. CAD patients were recruited from the cardiology clinic of Taichung Veterans General Hospital. Patients who were identified by cardiac catheterization as having at least 50 % stenosis of one major coronary artery and who were treated with statins for at least one month were enrolled in this study (n = 47). The subjects were randomly assigned to the placebo (n = 24) and LC groups (n = 23). The intervention was administered for 12 weeks. The levels of LC, lipid peroxide (malondialdehyde, MDA), antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)] activities, and inflammation markers [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] were measured in the 39 subjects (placebo, n = 19; LC, n = 20) who completed the study. The levels of LC (P = 0.04) and antioxidant enzyme activities (CAT, P = 0.02; SOD, P < 0.01; GPx, P < 0.01) were significantly increased; and the levels of MDA (P = 0.02) and inflammation markers (CRP, P < 0.01; IL-6, P = 0.03; TNF-α, P = 0.07) were significantly decreased after LC supplementation. In addition, the level of LC was significantly positively correlated with the antioxidant enzymes activity (CAT, β = 0.87, P = 0.02; SOD, β = 0.72, P <0.01) and negatively correlated with the inflammation marker (TNF-α, β = -0.10, P = 0.04) after intervention. In conclusion, LC supplement at a dose of 1000 mg/d may increase the antioxidative capacity and reduce the inflammation status in patients with CAD.