Effects of Platycodon Grandiflorum Extracts on Blood Sugar Regulation

• Main Authors: Wen, Mei-Jauan, 温美娟
• Other Authors: Wang, Shyang-Guang
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/4gbku3

碩士 === 中臺科技大學 === 藥物科技研究所 === 102 === The prevalence of metabolic syndrome has increased dramatically due to the sedentary lifestyle and the diet rich in fat and sugar. According to previous researches, Saponins isolated from the root of P. grandiflorum have shown novel benefecial effects on hyperglycemia and dyslipidemia in diabetic mice. It is known when activating insulin receptor ( IR ), insulin induces signaling pathway through IRS-1 ( Insulin receptor substrate 1 )、PDK ( Phosphoinositide-dependent kinase-1 ) , Akt ( Protein Kinase B ) and then enhancing the uptake of glucose through translocation of GLUT4 vesicles from cytoplasm to the cell membrane. In this study, we demonstrated that P. grandiflorum extract induced phosphorylation of IR, IRS-1, PDK, Akt in C2C12 myotube. P. grandiflorm extract improved 3H-glucose uptake in C2C12. In addition, the extract also had the beneficial effects on hyperglycemia in STZ/Nicotinamide-treated diabetic mice. In conclusion, P. grandiflorum extracts could regulate glucose metabolism in type 2 diabetes through increasing insulin sensitivity.