A Facile Entry to Synthesis β-Ketoamides from β-Enaminoesters Catalysed by Silver (I) Triflate

• Main Authors: Cheng-Tien Hsiao, 蕭呈恬
• Other Authors: Jeh-Jeng Wang
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/2dh4d6

碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 102 === A facile and efficient approach to synthesis β-ketoamides from β-enaminoesters via Ag(I) catalysis is described. A first catalytic protocol has been developed with broad substrate scope in good to excellent yields. The cross over experimentssuggested that the reaction underwent a new pathway and not through the traditional condensation intermediates ethyl benzoylacetateand aniline. In this reaction the C-O and C-N bond formations were undergone to give the desired compound. A gram scale synthesis was successfully demonstrated with the optimized reaction conditions.