| Summary: | 碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 102 === Napthaquinones are important class of biologically active compounds found in natural and pharmaceutical drugs. In this thesis, the novel synthetic strategy to construct naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives via a cycloaddition derived from versatile starting material such as 2-hydroxy -1,4-napthaquinone and Naphthol was reported.
This synthetic approach differs from traditional CuAAC (Copper Catalyzed Azide-Alkyne Cycloadditions) chemistry and has several key features such as metal free, atom economy, and eco-friendly process. On the other hand, the new products of our synthesis was assay by MTT assay (in vitro), which NP-4ME show the best antitumor activity against melanoma.
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