Design and Synthesis of Naphtho[2,3-d][1,2,3]triazole-4,9-dione Derivatives as Potential Anticancer Agents

碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 102 === Napthaquinones are important class of biologically active compounds found in natural and pharmaceutical drugs. In this thesis, the novel synthetic strategy to construct naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives via a cycloaddition derived from versa...

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Main Authors:	Ping-Fan Chen, 陳秉範
Other Authors:	Jeh-Jeng Wang
Format:	Others
Language:	zh-TW
Published:	2014
Online Access:	http://ndltd.ncl.edu.tw/handle/x85tku

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spelling	ndltd-TW-102KMC055370292019-05-15T21:43:13Z http://ndltd.ncl.edu.tw/handle/x85tku Design and Synthesis of Naphtho[2,3-d][1,2,3]triazole-4,9-dione Derivatives as Potential Anticancer Agents 設計與合成萘醌[2,3-d][1,2,3]三唑-4,9-雙酮抗癌潛力衍生物 Ping-Fan Chen 陳秉範碩士高雄醫學大學醫藥暨應用化學研究所 102 Napthaquinones are important class of biologically active compounds found in natural and pharmaceutical drugs. In this thesis, the novel synthetic strategy to construct naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives via a cycloaddition derived from versatile starting material such as 2-hydroxy -1,4-napthaquinone and Naphthol was reported. This synthetic approach differs from traditional CuAAC (Copper Catalyzed Azide-Alkyne Cycloadditions) chemistry and has several key features such as metal free, atom economy, and eco-friendly process. On the other hand, the new products of our synthesis was assay by MTT assay (in vitro), which NP-4ME show the best antitumor activity against melanoma. Jeh-Jeng Wang 王志鉦 2014 學位論文 ; thesis 91 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 102 === Napthaquinones are important class of biologically active compounds found in natural and pharmaceutical drugs. In this thesis, the novel synthetic strategy to construct naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives via a cycloaddition derived from versatile starting material such as 2-hydroxy -1,4-napthaquinone and Naphthol was reported. This synthetic approach differs from traditional CuAAC (Copper Catalyzed Azide-Alkyne Cycloadditions) chemistry and has several key features such as metal free, atom economy, and eco-friendly process. On the other hand, the new products of our synthesis was assay by MTT assay (in vitro), which NP-4ME show the best antitumor activity against melanoma.
author2	Jeh-Jeng Wang
author_facet	Jeh-Jeng Wang Ping-Fan Chen 陳秉範
author	Ping-Fan Chen 陳秉範
spellingShingle	Ping-Fan Chen 陳秉範 Design and Synthesis of Naphtho[2,3-d][1,2,3]triazole-4,9-dione Derivatives as Potential Anticancer Agents
author_sort	Ping-Fan Chen
title	Design and Synthesis of Naphtho[2,3-d][1,2,3]triazole-4,9-dione Derivatives as Potential Anticancer Agents
title_short	Design and Synthesis of Naphtho[2,3-d][1,2,3]triazole-4,9-dione Derivatives as Potential Anticancer Agents
title_full	Design and Synthesis of Naphtho[2,3-d][1,2,3]triazole-4,9-dione Derivatives as Potential Anticancer Agents
title_fullStr	Design and Synthesis of Naphtho[2,3-d][1,2,3]triazole-4,9-dione Derivatives as Potential Anticancer Agents
title_full_unstemmed	Design and Synthesis of Naphtho[2,3-d][1,2,3]triazole-4,9-dione Derivatives as Potential Anticancer Agents
title_sort	design and synthesis of naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potential anticancer agents
publishDate	2014
url	http://ndltd.ncl.edu.tw/handle/x85tku
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Design and Synthesis of Naphtho[2,3-d][1,2,3]triazole-4,9-dione Derivatives as Potential Anticancer Agents

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