Studies on the Sinapic Acid Derivatives and Chemical Constituents from the Herb of Gynura bicolor : The Improvements of the Cytotoxic Activity
碩士 === 高雄醫學大學 === 藥學研究所 === 102 === Gynura bicolor (Roxb. & Willd.) DC is widely distributed in certain areas of Asia and is very popular in vegetarian cuisine in Taiwan. Gynura Bicolor, a perennial plant in Pingtung、 Keelung of Taiwan, is a folk medicine in China1~3. The antioxidant activity an...
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ndltd-TW-102KMC055510082019-05-30T03:50:11Z http://ndltd.ncl.edu.tw/handle/4pb8bm Studies on the Sinapic Acid Derivatives and Chemical Constituents from the Herb of Gynura bicolor : The Improvements of the Cytotoxic Activity 子酸衍生物與紅鳳菜全草化學成分:改善細胞毒殺活性之研究 Shin-Chung Huang 黃信璋 碩士 高雄醫學大學 藥學研究所 102 Gynura bicolor (Roxb. & Willd.) DC is widely distributed in certain areas of Asia and is very popular in vegetarian cuisine in Taiwan. Gynura Bicolor, a perennial plant in Pingtung、 Keelung of Taiwan, is a folk medicine in China1~3. The antioxidant activity and treatment of liver diseases have been reported4~7. Furthermore, G. bicolor DC are used as a recipe to treat diabetes mellitus (anti-hyperglycemia) in some parts of China8~10. In our studies, we have isolated 7 components from this plant,and then we have found that 7 materials have potent activity in a cytotoxicity screening program against K562 (a leukemia cell) and MCF-7 (a breast cancer cell) cancer cell lines in vitro.. Whether the cytotoxic activity will increase or decrease depends on what we add to the side chain. We hope that we can make better cytotoxicity on sinapic acid by replacing the carboxylic group11. We designed on the basis of six ring or six heterocyclic ring12~15 to react with sinapic acid,such as 2-aminopyridine、4-aminopyridine and totally 5 synthetic compounds. We compared the 7 materials isolated from Gynura bicolor with the 5 compounds we have synthesized. They showed much better activity . We hope we can get these compounds by various methods. As a result, our components and semi-synthetic products demonstrate different outcome about their cytotoxic activity. Mei-Ing-Chung 鍾美英 2014 學位論文 ; thesis 72 zh-TW |
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碩士 === 高雄醫學大學 === 藥學研究所 === 102 === Gynura bicolor (Roxb. & Willd.) DC is widely distributed in certain areas of Asia and is very popular in vegetarian cuisine in Taiwan. Gynura Bicolor, a perennial plant in Pingtung、 Keelung of Taiwan, is a folk medicine in China1~3. The antioxidant activity and treatment of liver diseases have been reported4~7. Furthermore, G. bicolor DC are used as a recipe to treat diabetes mellitus (anti-hyperglycemia) in some parts of China8~10. In our studies, we have isolated 7 components from this plant,and then we have found that 7 materials have potent activity in a cytotoxicity screening program against K562 (a leukemia cell) and MCF-7 (a breast cancer cell) cancer cell lines in vitro.. Whether the cytotoxic activity will increase or decrease depends on what we add to the side chain. We hope that we can make better cytotoxicity on sinapic acid by replacing the carboxylic group11. We designed on the basis of six ring or six heterocyclic ring12~15 to react with sinapic acid,such as 2-aminopyridine、4-aminopyridine and totally 5 synthetic compounds. We compared the 7 materials isolated from Gynura bicolor with the 5 compounds we have synthesized. They showed much better activity . We hope we can get these compounds by various methods. As a result, our components and semi-synthetic products demonstrate different outcome about their cytotoxic activity.
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author2 |
Mei-Ing-Chung |
author_facet |
Mei-Ing-Chung Shin-Chung Huang 黃信璋 |
author |
Shin-Chung Huang 黃信璋 |
spellingShingle |
Shin-Chung Huang 黃信璋 Studies on the Sinapic Acid Derivatives and Chemical Constituents from the Herb of Gynura bicolor : The Improvements of the Cytotoxic Activity |
author_sort |
Shin-Chung Huang |
title |
Studies on the Sinapic Acid Derivatives and Chemical Constituents from the Herb of Gynura bicolor : The Improvements of the Cytotoxic Activity |
title_short |
Studies on the Sinapic Acid Derivatives and Chemical Constituents from the Herb of Gynura bicolor : The Improvements of the Cytotoxic Activity |
title_full |
Studies on the Sinapic Acid Derivatives and Chemical Constituents from the Herb of Gynura bicolor : The Improvements of the Cytotoxic Activity |
title_fullStr |
Studies on the Sinapic Acid Derivatives and Chemical Constituents from the Herb of Gynura bicolor : The Improvements of the Cytotoxic Activity |
title_full_unstemmed |
Studies on the Sinapic Acid Derivatives and Chemical Constituents from the Herb of Gynura bicolor : The Improvements of the Cytotoxic Activity |
title_sort |
studies on the sinapic acid derivatives and chemical constituents from the herb of gynura bicolor : the improvements of the cytotoxic activity |
publishDate |
2014 |
url |
http://ndltd.ncl.edu.tw/handle/4pb8bm |
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