| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所 === 102 === A principal goal of organometallic chemistry is the catalytic synthesis of organic compounds by using the chemistry of organic ligands covalently bound to transition metals. The palladium-catalyzed allylation of N-nucleophiles was an established and efficient method, which has been widely applied to organic chemistry.
Utilizing the prevalence of indole nucleus in biologically active compounds, the direct C3-functionalization or N-functionalization of 2,3-disubstituted indoles represent an important problem.
In this study, the palladium-catalyzed 2,3-disubstitued indoles with allylic alcohols in benzene was investigated under various conditions. Furthermore, microwave has been widely applied to shorten reaction time in organic synthesis. Herein, we develop a new highly selective method. This method provide particularly convenient, efficient, and selective.
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