The study of PTSD by Cav3.2 T-type Calcium Channel Knockout Mouse Microarray Dataset Analysis

• Main Authors: Che-Yen Su, 蘇哲彥
• Other Authors: Meng-Hsiun Tsai
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/52751510056459992517

碩士 === 國立中興大學 === 基因體暨生物資訊學研究所 === 102 === Post-traumatic stress disorder (PTSD) is a mental disorder, results from the exposure to huge post-traumatic stress. The disease process will also influence the different levels of gene expression in the brain. Mice after electric shock training will produce contextual memory-related experience, but it also constitutes a of PTSD condition－Experience major trauma. Trace fear conditioning test with mice model is also PTSD-related experiment commonly used operations. Cav3.2 T-type calcium channel was associated with contextual memory, so use knockout operation on to compare. This study used bio-statistical methods of the total eight sets of gene microarray data processing in order to filter out potentially relevant target genes. Using the p-Value to be the threshold, and the Information Gain as supports validation. Choose a series of target genes, and then through the IPA（Ingenuity Pathways Analysis） to construct the gene networks and a series of biochemical and medicinal functional analysis. Find some target gene may help to understand PTSD causes to further use for biomedical research.